Entity Details

Primary name Tlr2
Entity type gene
Source Source Link

Details

PrimaryID24088
RefseqGene
SymbolTlr2
Nametoll-like receptor 2
Chromosome3
Location3
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-01-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsTLR2_MOUSE

GO terms

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GOName
GO:0001530 lipopolysaccharide binding
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001775 cell activation
GO:0001819 positive regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0002238 response to molecule of fungal origin
GO:0002687 positive regulation of leukocyte migration
GO:0002730 regulation of dendritic cell cytokine production
GO:0002752 cell surface pattern recognition receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006691 leukotriene metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007252 I-kappaB phosphorylation
GO:0007612 learning
GO:0008285 negative regulation of cell population proliferation
GO:0009617 response to bacterium
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0014005 microglia development
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030670 phagocytic vesicle membrane
GO:0030837 negative regulation of actin filament polymerization
GO:0031226 intrinsic component of plasma membrane
GO:0032289 central nervous system myelin formation
GO:0032493 response to bacterial lipoprotein
GO:0032494 response to peptidoglycan
GO:0032695 negative regulation of interleukin-12 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032728 positive regulation of interferon-beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032741 positive regulation of interleukin-18 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0035325 Toll-like receptor binding
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:0038023 signaling receptor activity
GO:0038187 pattern recognition receptor activity
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0042496 detection of diacyl bacterial lipopeptide
GO:0042497 triacyl lipopeptide binding
GO:0042498 diacyl lipopeptide binding
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0042995 cell projection
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046209 nitric oxide metabolic process
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050135 NAD(P)+ nucleosidase activity
GO:0050729 positive regulation of inflammatory response
GO:0050765 negative regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051964 negative regulation of synapse assembly
GO:0060907 positive regulation of macrophage cytokine production
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070542 response to fatty acid
GO:0070891 lipoteichoic acid binding
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071346 cellular response to interferon-gamma
GO:0071723 lipopeptide binding
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0071727 cellular response to triacyl bacterial lipopeptide
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1904417 positive regulation of xenophagy
GO:1904466 positive regulation of matrix metallopeptidase secretion

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
Tlr2Cd22IntAct25187624 details
Tlr2Cd33IntAct25187624 details
Tlr2SiglecfIntAct25187624 details
Tlr2BGNmatrixdb24480070 details
Tlr2Hmgb1UniProt16267105 details
Tlr2Myd88DIP, UniProt16832055 29990310 details