Entity Details

Primary name HGS_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ99LI8
EntryNameHGS_MOUSE
FullNameHepatocyte growth factor-regulated tyrosine kinase substrate
TaxID10090
Evidenceevidence at protein level
Length775
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesHgs

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006622 protein targeting to lysosome
GO:0008333 endosome to lysosome transport
GO:0010324 membrane invagination
GO:0010628 positive regulation of gene expression
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0016020 membrane
GO:0016525 negative regulation of angiogenesis
GO:0019904 protein domain specific binding
GO:0030141 secretory granule
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031901 early endosome membrane
GO:0032585 multivesicular body membrane
GO:0033565 ESCRT-0 complex
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043405 regulation of MAP kinase activity
GO:0044389 ubiquitin-like protein ligase binding
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046872 metal ion binding
GO:0072657 protein localization to membrane
GO:0140036 ubiquitin-dependent protein binding
GO:1903543 positive regulation of exosomal secretion

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome membrane
Endosome

Domains

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DomainNameCategoryType
IPR000306 FYVE zinc fingerDomainDomain
IPR002014 VHS domainDomainDomain
IPR003903 Ubiquitin interacting motifSiteConserved site
IPR008942 ENTH/VHSFamilyHomologous superfamily
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017073 Ubiquitin binding protein, Hrs/VPS27FamilyFamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domainDomainDomain

Diseases

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