Entity Details

Primary name Map2k1
Entity type gene
Source Source Link

Details

PrimaryID26395
RefseqGene
SymbolMap2k1
Namemitogen-activated protein kinase kinase 1
Chromosome9
Location9 34.55 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-25
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsMP2K1_MOUSE

GO terms

Show/Hide Table
GOName
GO:0000187 obsolete activation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0003056 regulation of vascular associated smooth muscle contraction
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014069 postsynaptic density
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030878 thyroid gland development
GO:0031267 small GTPase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0032402 melanosome transport
GO:0032839 dendrite cytoplasm
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034111 negative regulation of homotypic cell-cell adhesion
GO:0042593 glucose homeostasis
GO:0043204 perikaryon
GO:0043539 protein serine/threonine kinase activator activity
GO:0043547 positive regulation of GTPase activity
GO:0044877 protein-containing complex binding
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045933 positive regulation of muscle contraction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0047485 protein N-terminus binding
GO:0047496 vesicle transport along microtubule
GO:0048313 Golgi inheritance
GO:0048471 perinuclear region of cytoplasm
GO:0048538 thymus development
GO:0048678 response to axon injury
GO:0048679 regulation of axon regeneration
GO:0048812 neuron projection morphogenesis
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0051384 response to glucocorticoid
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070328 triglyceride homeostasis
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:0097110 scaffold protein binding
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport
GO:2001171 positive regulation of ATP biosynthetic process

Diseases

Show/Hide Table

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
Map2k1BrafBioGRID, MINT27034005 8668348 details
Map2k1Dnajc27IntAct24746703 details
Map2k1CPNE1BioGRID12522145 details
Map2k1CPNE4BioGRID12522145 details
Map2k1Raf1BioGRID11435472 14636584 20956560 23055494 8668348 details
Map2k1Ksr1BioGRID18332145 21144847 details
Map2k1Myod1BioGRID21454680 details
Map2k1Mapk1BioGRID11435472 21144847 32325033 details
Map2k1Grin2bBioGRID, IntAct10862698 16635246 details
Map2k1PIN1bhf-ucl20179103 details
Map2k1Mapk8ip3bhf-ucl10523642 details
Map2k1Nek10BioGRID20956560 details
Map2k1BrapBioGRID18332145 details
Map2k1CflarBioGRID17110930 details
Map2k1Axin1BioGRID12223491 18316368 details
Map2k1PxnBioGRID14636584 details
Map2k1Pebp1BioGRID23055494 details
Map2k1Mapkbp1BioGRID19385034 details
Map2k1PrkceIntAct11139474 details
Map2k1Grin1BioGRID, IntAct, MINT10862698 16635246 details
Map2k1Agap2BioGRID, IntAct28706196 details
Map2k1Syngap1BioGRID, IntAct28706196 details
Map2k1Foxp3BioGRID22922362 details
Map2k1EedBioGRID24457600 details
Map2k1Ppp1r9bBioGRID30562941 details
Map2k1Atxn1BioGRID30457570 details
Map2k1Tia1BioGRID27160897 details
Map2k1MaptBioGRID30068389 details
Map2k1Rps6ka2BioGRID32325033 details
Map2k1BlvraBioGRID32325033 details
Map2k1Iqgap1BioGRID32325033 details
Map2k1Lamtor3BioGRID32325033 details
Map2k1Map2k2BioGRID32325033 details
Map2k1YwhaeBioGRID32325033 details
Map2k1Lamtor2BioGRID32325033 details
Map2k1Mapk3BioGRID32325033 details
Map2k1Slc6a4BioGRID32581705 details