Entity Details

Primary name Mapk1
Entity type gene
Source Source Link

Details

PrimaryID26413
RefseqGene
SymbolMapk1
Namemitogen-activated protein kinase 1
Chromosome16
Location16 10.53 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-25
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsMK01_MOUSE

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0003690 double-stranded DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007507 heart development
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014032 neural crest cell development
GO:0014069 postsynaptic density
GO:0015966 diadenosine tetraphosphate biosynthetic process
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0019858 cytosine metabolic process
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030278 regulation of ossification
GO:0030424 axon
GO:0030641 regulation of cellular pH
GO:0030878 thyroid gland development
GO:0031143 pseudopodium
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031647 regulation of protein stability
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032496 response to lipopolysaccharide
GO:0032839 dendrite cytoplasm
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0033598 mammary gland epithelial cell proliferation
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0038127 ERBB signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0042473 outer ear morphogenesis
GO:0042802 identical protein binding
GO:0043204 perikaryon
GO:0043330 response to exogenous dsRNA
GO:0043627 response to estrogen
GO:0045596 negative regulation of cell differentiation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046697 decidualization
GO:0048538 thymus development
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051493 regulation of cytoskeleton organization
GO:0051973 positive regulation of telomerase activity
GO:0060020 Bergmann glial cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060291 long-term synaptic potentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0060716 labyrinthine layer blood vessel development
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0070371 ERK1 and ERK2 cascade
GO:0070849 response to epidermal growth factor
GO:0071276 cellular response to cadmium ion
GO:0071310 cellular response to organic substance
GO:0071356 cellular response to tumor necrosis factor
GO:0072584 caveolin-mediated endocytosis
GO:0072686 mitotic spindle
GO:0090170 regulation of Golgi inheritance
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0120041 positive regulation of macrophage proliferation
GO:1903351 cellular response to dopamine
GO:1904355 positive regulation of telomere capping
GO:2000641 regulation of early endosome to late endosome transport

Diseases

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Interactions

103 interactions

InteractorPartnerSourcesPublicationsLink
Mapk1Atf2BioGRID, MINT15192015 15304344 details
Mapk1Mknk2IntAct15102471 details
Mapk1Mknk1IntAct15102471 details
Mapk1Rhbdf2IntAct15102471 details
Mapk1Zmynd11IntAct15102471 details
Mapk1Rps6ka4IntAct15102471 details
Mapk1Nupl1IntAct15102471 details
Mapk1Cep135IntAct15102471 details
Mapk1CroccIntAct15102471 details
Mapk1BCL2L11IntAct16282323 details
Mapk1ELK1IntAct16533805 details
Mapk1GSK3BIntAct18045539 details
Mapk1Sqstm1BioGRID, MINT16517408 20154642 details
Mapk1Dusp6MINT16148006 details
Mapk1PtprrMINT10419510 16148006 details
Mapk1DUSP9MINT11988087 details
Mapk1Dnajc27IntAct24746703 details
Mapk1MAP2K1HPIDb20554783 details
Mapk1CebpbDIP17264204 details
Mapk1Klf4DIP22307056 details
Mapk1SNAI1DIP23644467 details
Mapk1KLF11BioGRID12006497 details
Mapk1TP53BioGRID10958792 details
Mapk1Pea15aBioGRID15537391 32325033 details
Mapk1Elk1BioGRID11435472 15767678 9687507 details
Mapk1Itgb5BioGRID11857080 details
Mapk1Dusp2BioGRID16288922 details
Mapk1Eif4ebp1BioGRID8939971 details
Mapk1Eif4ebp2BioGRID8939971 details
Mapk1MbpBioGRID10362356 15544353 details
Mapk1PxnBioGRID14636584 details
Mapk1BCL2L1BioGRID16282323 details
Mapk1NanogBioGRID24793005 details
Mapk1Rps6ka3BioGRID24793005 details
Mapk1Map2k1BioGRID11435472 21144847 32325033 details
Mapk1PTPN5BioGRID25583483 details
Mapk1Tnfrsf1aBioGRID15865443 details
Mapk1Itga2bBioGRID30333137 details
Mapk1NR4A2BioGRID17681692 details
Mapk1Grin2bBioGRID, IntAct10862698 16635246 details
Mapk1Dlg4BioGRID, IntAct19455133 27507650 28671696 details
Mapk1Mapk1IntAct26267534 details
Mapk1Efnb3DIP20410461 details
Mapk1Per1DIP21179498 details
Mapk1Cry1DIP21179498 details
Mapk1Per2DIP21179498 details
Mapk1Cry2DIP21179498 details
Mapk1Top2aBioGRID10207078 details
Mapk1Pcyt1aBioGRID19332566 details
Mapk1BlnkBioGRID15087455 details
Mapk1CttnBioGRID22514278 details
Mapk1Vrk3BioGRID18035061 details
Mapk1Dusp3BioGRID18035061 32325033 details
Mapk1Capn2BioGRID14993287 32325033 details
Mapk1Metap2BioGRID15544353 details
Mapk1FerBioGRID15567065 details
Mapk1Ksr1BioGRID19114553 details
Mapk1Mapk8ip3BioGRID21156008 details
Mapk1Grin1BioGRID, IntAct, MINT10862698 16635246 details
Mapk1Hmga2IntAct26045162 details
Mapk1Pde4dipBioGRID, IntAct28671696 details
Mapk1TnikBioGRID, IntAct28671696 details
Mapk1Dlgap1BioGRID, IntAct27507650 28671696 details
Mapk1Shank3BioGRID, IntAct27507650 28671696 details
Mapk1Agap2BioGRID, IntAct28706196 details
Mapk1Syngap1BioGRID, IntAct28706196 details
Mapk1DISC1MINT29961565 details
Mapk1EedBioGRID24457600 details
Mapk1Fancd2BioGRID28378742 details
Mapk1Ppp1r9bBioGRID30562941 32325033 details
Mapk1Trpv1BioGRID30335684 details
Mapk1Atxn1BioGRID30457570 details
Mapk1Tia1BioGRID27160897 details
Mapk1MaptBioGRID30068389 details
Mapk1Dapk1BioGRID32325033 details
Mapk1Gnb3BioGRID32325033 details
Mapk1Slc9a1BioGRID32325033 details
Mapk1Arhgef2BioGRID32325033 details
Mapk1BlvraBioGRID32325033 details
Mapk1CenpeBioGRID32325033 details
Mapk1Cuedc2BioGRID32325033 details
Mapk1DhpsBioGRID32325033 details
Mapk1GmfbBioGRID32325033 details
Mapk1Gnai3BioGRID32325033 details
Mapk1Map2k2BioGRID32325033 details
Mapk1Gnai1BioGRID32325033 details
Mapk1Gnai2BioGRID32325033 details
Mapk1Gnao1BioGRID32325033 details
Mapk1Gnb5BioGRID32325033 details
Mapk1Lamtor3BioGRID32325033 details
Mapk1Mapk12BioGRID32325033 details
Mapk1NefhBioGRID32325033 details
Mapk1PrkcaBioGRID32325033 details
Mapk1PrkcdBioGRID32325033 details
Mapk1Rps6ka1BioGRID32325033 details
Mapk1Mapk3BioGRID32325033 details
Mapk1Ppp2r5cBioGRID32325033 details
Mapk1Rps6ka2BioGRID32325033 details
Mapk1Syne2BioGRID32325033 details
Mapk1Eif4e3BioGRID32325033 details
Mapk1Ntn1BioGRID32325033 details
Mapk1CfdBioGRID30550785 details
Mapk1Fndc5BioGRID30550785 details