Entity Details

Primary name Sirt6
Entity type gene
Source Source Link

Details

PrimaryID50721
RefseqGene
SymbolSirt6
Namesirtuin 6
Chromosome10
Location10 39.72 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-04-17
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSIR6_MOUSE

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006284 base-excision repair
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0031940 positive regulation of chromatin silencing at telomere
GO:0032206 positive regulation of telomere maintenance
GO:0033558 protein deacetylase activity
GO:0042593 glucose homeostasis
GO:0045820 negative regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046325 negative regulation of glucose import
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0048146 positive regulation of fibroblast proliferation
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
GO:0099115 chromosome, subtelomeric region
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901485 positive regulation of transcription factor catabolic process
GO:1902732 positive regulation of chondrocyte proliferation
GO:1905549 positive regulation of subtelomeric heterochromatin assembly
GO:1905555 positive regulation of blood vessel branching
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000648 positive regulation of stem cell proliferation

Diseases

Show/Hide Table

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
Sirt6APEX1BioGRID26063178 details
Sirt6MUTYHBioGRID26063178 details
Sirt6MycIntAct23217706 details
Sirt6Pou5f1BioGRID22083510 details
Sirt6Il1rl1IntAct19135889 details