Entity Details

Primary name Fbxw7
Entity type gene
Source Source Link

Details

PrimaryID50754
RefseqGene
SymbolFbxw7
NameF-box and WD-40 domain protein 7
Chromosome3
Location3 37.7 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-04-17
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsFBXW7_MOUSE

GO terms

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GOName
GO:0001570 vasculogenesis
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0007062 sister chromatid cohesion
GO:0007219 Notch signaling pathway
GO:0010629 negative regulation of gene expression
GO:0010992 ubiquitin recycling
GO:0016021 integral component of membrane
GO:0016567 protein ubiquitination
GO:0019005 SCF ubiquitin ligase complex
GO:0030324 lung development
GO:0030332 cyclin binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050816 phosphothreonine residue binding
GO:0050821 protein stabilization
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0097027 ubiquitin-protein transferase activator activity
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1903146 regulation of autophagy of mitochondrion
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2001205 negative regulation of osteoclast development

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
Fbxw7Npm1BioGRID18625840 details
Fbxw7PrkceBioGRID20815813 details
Fbxw7CREB3L1BioGRID23955342 details
Fbxw7CREB3L2BioGRID23955342 details
Fbxw7MyrfBioGRID29472293 details
Fbxw7Zeb2BioGRID30783098 details
Fbxw7Hp1bp3BioGRID30783098 details
Fbxw7NOTCH1DIP25344755 details
Fbxw7MYBBioGRID19421138 21092141 details
Fbxw7Pin1BioGRID22608923 details
Fbxw7Mcl1BioGRID21368834 details
Fbxw7CEBPABioGRID20534483 details
Fbxw7PrkcaBioGRID20815813 details
Fbxw7PrkcbBioGRID20815813 details
Fbxw7PrkcdBioGRID20815813 details
Fbxw7PrkczBioGRID20815813 details
Fbxw7Cul1BioGRID11735228 25670854 29472293 details
Fbxw7Skp1BioGRID11735228 23955342 25670854 29472293 details
Fbxw7Gata2BioGRID25670854 details
Fbxw7MycBioGRID25670854 29472293 details
Fbxw7MybBioGRID21092141 25670854 29472293 details
Fbxw7Ppargc1aBioGRID25918410 details
Fbxw7Srebf2BioGRID29472293 details
Fbxw7Srebf1BioGRID29472293 details
Fbxw7Tgif1BioGRID29472293 details
Fbxw7Tgif2BioGRID29472293 details
Fbxw7Creb3l2BioGRID29472293 details
Fbxw7Creb3l1BioGRID29472293 details
Fbxw7Klf5BioGRID29472293 details
Fbxw7MtorMINT21076392 details
Fbxw7DeptorBioGRID30783098 details
Fbxw7Itga3BioGRID30783098 details
Fbxw7Rad51BioGRID30783098 details
Fbxw7Elk1BioGRID30783098 details
Fbxw7Fabp6BioGRID30783098 details
Fbxw7DekBioGRID30783098 details
Fbxw7Zswim2BioGRID30783098 details
Fbxw7Prdx6BioGRID30783098 details
Fbxw7Cdc16BioGRID30783098 details
Fbxw7Fgf1BioGRID30783098 details
Fbxw7Elk3BioGRID30783098 details
Fbxw7Prdm6BioGRID30783098 details
Fbxw7Hes6BioGRID30783098 details
Fbxw7Ppp2r5aBioGRID30783098 details
Fbxw7Timp4BioGRID30783098 details
Fbxw7Tada2aBioGRID30783098 details
Fbxw7Nomo1BioGRID30783098 details
Fbxw7Znrf3BioGRID30783098 details
Fbxw7NanogBioGRID30783098 details
Fbxw7Rnf146BioGRID30783098 details
Fbxw7Glis1BioGRID30783098 details
Fbxw7Nek9BioGRID30783098 details