Entity Details

Primary name Chek2
Entity type gene
Source Source Link

Details

PrimaryID50883
RefseqGene
SymbolChek2
Namecheckpoint kinase 2
Chromosome5
Location5
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-04-28
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsCHK2_MOUSE

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000781 chromosome, telomeric region
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 response to gamma radiation
GO:0016301 kinase activity
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035690 cellular response to drug
GO:0042176 regulation of protein catabolic process
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044257 cellular protein catabolic process
GO:0044773 mitotic DNA damage checkpoint signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0051301 cell division
GO:0071480 cellular response to gamma radiation
GO:0090307 mitotic spindle assembly
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903416 response to glycoside
GO:1903926 cellular response to bisphenol A
GO:2000002 negative regulation of DNA damage checkpoint
GO:2000210 positive regulation of anoikis

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
Chek2Rchy1BioGRID23449389 details
Chek2CHEK2BioGRID, IntAct20360068 details
Chek2JPH1BioGRID, IntAct20360068 details
Chek2STK38BioGRID, IntAct20360068 details
Chek2BRD8BioGRID20360068 details