Entity Details

Primary name SOST_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ99P68
EntryNameSOST_MOUSE
FullNameSclerostin
TaxID10090
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated2002-03-05
DateModified2021-06-02

Ontological Relatives

GenesSost

GO terms

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GOName
GO:0001503 ossification
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0008134 transcription factor binding
GO:0008201 heparin binding
GO:0009612 response to mechanical stimulus
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030514 negative regulation of BMP signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032991 protein-containing complex
GO:0036122 BMP binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR008835 Sclerostin/Sclerostin domain-containing protein 1FamilyFamily
IPR015665 SclerostinFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SOST_MOUSELRP5_MOUSEBioGRID17002572 details
SOST_MOUSELRP6_MOUSEBioGRID17002572 details