Entity Details

Primary name PRP8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ99PV0
EntryNamePRP8_MOUSE
FullNamePre-mRNA-processing-splicing factor 8
TaxID10090
Evidenceevidence at protein level
Length2335
SequenceStatuscomplete
DateCreated2005-06-07
DateModified2021-06-02

Ontological Relatives

GenesPrpf8

GO terms

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GOName
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0005634 nucleus
GO:0005682 U5 snRNP
GO:0008237 metallopeptidase activity
GO:0016607 nuclear speck
GO:0017070 U6 snRNA binding
GO:0030532 small nuclear ribonucleoprotein complex
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030623 U5 snRNA binding
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070122 isopeptidase activity
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:0097157 pre-mRNA intronic binding

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000555 JAB1/MPN/MOV34 metalloenzyme domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012591 PRO8NT domainDomainDomain
IPR012592 PROCN domainDomainDomain
IPR012984 PROCT domainDomainDomain
IPR019580 Pre-mRNA-processing-splicing factor 8, U6-snRNA-bindingDomainDomain
IPR019581 Pre-mRNA-processing-splicing factor 8, U5-snRNA-bindingDomainDomain
IPR019582 RNA recognition motif, spliceosomal PrP8DomainDomain
IPR021983 PRP8 domain IV coreDomainDomain
IPR027652 Pre-mRNA-processing-splicing factor 8FamilyFamily
IPR037518 MPN domainDomainDomain
IPR042516 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamilyFamilyHomologous superfamily
IPR043172 Prp8 RNase domain IV, palm regionFamilyHomologous superfamily
IPR043173 Prp8 RNase domain IV, fingers regionFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PRP8_MOUSEITB1_MOUSEBioGRID30333137 details
PRP8_MOUSEITB3_MOUSEBioGRID30333137 details