Entity Details

Primary name Tbk1
Entity type gene
Source Source Link

Details

PrimaryID56480
RefseqGene
SymbolTbk1
NameTANK-binding kinase 1
Chromosome10
Location10
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-02-02
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsTBK1_MOUSE

GO terms

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GOName
GO:0002218 activation of innate immune response
GO:0003676 nucleic acid binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016239 positive regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019903 protein phosphatase binding
GO:0031323 regulation of cellular metabolic process
GO:0032479 regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044565 dendritic cell proliferation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050830 defense response to Gram-positive bacterium
GO:0051219 phosphoprotein binding
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904417 positive regulation of xenophagy

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
Tbk1TankBioGRID, DIP, MINT10581243 18583960 23746807 27776110 details
Tbk1Sting1DIP, InnateDB, IntAct22000020 22728658 23142775 details
Tbk1OptnBioGRID, MINT21862579 27086836 details
Tbk1Tbk1BioGRID, DIP22728658 23746807 details
Tbk1IRF3DIP23746807 details
Tbk1TANKBioGRID10581243 details
Tbk1Irf1BioGRID17468758 details
Tbk1Rnf41BioGRID19483718 details
Tbk1Irf3BioGRID21862579 details
Tbk1Traf3ip2BioGRID22851696 details
Tbk1IRF1BioGRID23746807 details
Tbk1Tbkbp1BioGRID, MINT18583960 32325033 details
Tbk1Ticam1DIP, InnateDB21441935 22454496 details
Tbk1Zbp1DIP18375758 details
Tbk1TraipBioGRID22945920 details
Tbk1Ddx58BioGRID23950712 details
Tbk1SykBioGRID23962979 details
Tbk1OPTNBioGRID26376340 details
Tbk1Traf3BioGRID26474655 32324863 details
Tbk1Rnf128BioGRID27776110 details
Tbk1IkbkgBioGRID27776110 details
Tbk1Wdr48BioGRID29138248 details
Tbk1Usp1BioGRID29138248 details
Tbk1TnfBioGRID30420664 details
Tbk1Ptk2BioGRID31690171 details
Tbk1Traf2MINT10581243 details
Tbk1YwhabIntAct16635246 details
Tbk1Ddx3xMINT18583960 details
Tbk1Ddx41InnateDB21892174 details
Tbk1Azi2BioGRID, IntAct21903422 details
Tbk1Mib1BioGRID, IntAct21903422 details
Tbk1Map3k14InnateDB23023393 details
Tbk1IcosIntAct27135603 details
Tbk1Fxr1BioGRID, IntAct28671696 details
Tbk1C9orf72BioGRID, MINT27103069 details
Tbk1EedBioGRID24457600 details
Tbk1Myd88BioGRID30108181 details
Tbk1Atg16l1BioGRID30196744 details
Tbk1Dtx4BioGRID32325033 details
Tbk1Eps8BioGRID32325033 details
Tbk1Fbf1BioGRID32325033 details
Tbk1Mib2BioGRID32325033 details