Entity Details

Primary name Sphk2
Entity type gene
Source Source Link

Details

PrimaryID56632
RefseqGene
SymbolSphk2
Namesphingosine kinase 2
Chromosome7
Location7
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-08-11
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSPHK2_MOUSE

GO terms

Show/Hide Table
GOName
GO:0000786 nucleosome
GO:0001568 blood vessel development
GO:0001727 lipid kinase activity
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0003951 NAD+ kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006665 sphingolipid metabolic process
GO:0006669 sphinganine-1-phosphate biosynthetic process
GO:0006670 sphingosine metabolic process
GO:0007420 brain development
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell population proliferation
GO:0008481 sphinganine kinase activity
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0017050 D-erythro-sphingosine kinase activity
GO:0030308 negative regulation of cell growth
GO:0031064 negative regulation of histone deacetylation
GO:0031493 nucleosomal histone binding
GO:0032736 positive regulation of interleukin-13 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033008 positive regulation of mast cell activation involved in immune response
GO:0038036 sphingosine-1-phosphate receptor activity
GO:0043065 positive regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0043306 positive regulation of mast cell degranulation
GO:0043977 histone H2A-K5 acetylation
GO:0043980 histone H2B-K12 acetylation
GO:0045815 positive regulation of gene expression, epigenetic
GO:0046512 sphingosine biosynthetic process
GO:0090037 positive regulation of protein kinase C signaling
GO:0090280 positive regulation of calcium ion import
GO:1901726 negative regulation of histone deacetylase activity
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904959 regulation of cytochrome-c oxidase activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2001169 regulation of ATP biosynthetic process

Diseases

Show/Hide Table

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
Sphk2FynIntAct16316995 details
Sphk2LYNIntAct16316995 details
Sphk2FYNIntAct16316995 details
Sphk2YwhazIntAct19562802 details
Sphk2Phb2UniProt20959514 details