Entity Details

Primary name Gsk3b
Entity type gene
Source Source Link

Details

PrimaryID56637
RefseqGene
SymbolGsk3b
Nameglycogen synthase kinase 3 beta
Chromosome16
Location16
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-08-11
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsGSK3B_MOUSE

GO terms

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GOName
GO:0000320 re-entry into mitotic cell cycle
GO:0001558 regulation of cell growth
GO:0001837 epithelial to mesenchymal transition
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005977 glycogen metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006983 ER overload response
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007520 myoblast fusion
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008286 insulin receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010043 response to zinc ion
GO:0010508 positive regulation of autophagy
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010822 positive regulation of mitochondrion organization
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0014043 negative regulation of neuron maturation
GO:0014069 postsynaptic density
GO:0014902 myotube differentiation
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0021766 hippocampus development
GO:0030010 establishment of cell polarity
GO:0030011 maintenance of cell polarity
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030516 regulation of axon extension
GO:0030877 beta-catenin destruction complex
GO:0031175 neuron projection development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032007 negative regulation of TOR signaling
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032886 regulation of microtubule-based process
GO:0032991 protein-containing complex
GO:0033690 positive regulation of osteoblast proliferation
GO:0034236 protein kinase A catalytic subunit binding
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0034452 dynactin binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035733 hepatic stellate cell activation
GO:0036016 cellular response to interleukin-3
GO:0042752 regulation of circadian rhythm
GO:0042981 regulation of apoptotic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043227 membrane-bounded organelle
GO:0043407 negative regulation of MAP kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0044027 hypermethylation of CpG island
GO:0044297 cell body
GO:0045121 membrane raft
GO:0045444 fat cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045773 positive regulation of axon extension
GO:0045886 negative regulation of synaptic assembly at neuromuscular junction
GO:0045887 positive regulation of synaptic assembly at neuromuscular junction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0046827 positive regulation of protein export from nucleus
GO:0046849 bone remodeling
GO:0048156 tau protein binding
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048814 regulation of dendrite morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050770 regulation of axonogenesis
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051059 NF-kappaB binding
GO:0060070 canonical Wnt signaling pathway
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070840 dynein complex binding
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071109 superior temporal gyrus development
GO:0071260 cellular response to mechanical stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090290 positive regulation of osteoclast proliferation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097284 hepatocyte apoptotic process
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0099159 regulation of modification of postsynaptic structure
GO:0106027 neuron projection organization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0150101 regulation of microtubule anchoring at centrosome
GO:1900181 negative regulation of protein localization to nucleus
GO:1900271 regulation of long-term synaptic potentiation
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904339 negative regulation of dopaminergic neuron differentiation
GO:1904646 cellular response to amyloid-beta
GO:1904780 negative regulation of protein localization to centrosome
GO:1904781 positive regulation of protein localization to centrosome
GO:1990904 ribonucleoprotein complex
GO:1990909 Wnt signalosome
GO:2000171 negative regulation of dendrite development
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:2000738 positive regulation of stem cell differentiation
GO:2001223 negative regulation of neuron migration

Diseases

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Interactions

110 interactions

InteractorPartnerSourcesPublicationsLink
Gsk3bAxin1bhf-ucl, BioGRID, MINT10318824 14734535 18316368 19107203 19581931 21242974 22682247 25331900 details
Gsk3bBHLHE40IntAct23555304 details
Gsk3bBhlhe41IntAct23555304 details
Gsk3bCSNK2BIntAct23555304 details
Gsk3bBtrcIntAct23555304 details
Gsk3bLRP6bhf-ucl19107203 details
Gsk3bCtnnb1bhf-ucl, BioGRID10318824 12874278 15327768 19107203 32325033 details
Gsk3bAxin2BioGRID9554852 details
Gsk3bCtnnd1BioGRID19706605 details
Gsk3bNfe2l2BioGRID21245377 details
Gsk3bCops8BioGRID19576224 details
Gsk3bAkt1BioGRID18851840 20576936 21084607 32325033 details
Gsk3bArrb2BioGRID16051150 details
Gsk3bAkt2BioGRID20576936 details
Gsk3bMcl1BioGRID22976837 details
Gsk3bCebpbBioGRID11278638 details
Gsk3bMaptBioGRID23362255 30068389 details
Gsk3bEpm2aIntAct16959610 details
Gsk3bDisc1IntAct19303846 details
Gsk3bLrp6MINT22491013 details
Gsk3bDact2UniProt21718540 details
Gsk3bDact1UniProt21718540 details
Gsk3bPrkacabhf-ucl11035810 details
Gsk3bDzip1DIP25860027 details
Gsk3bE2f1BioGRID18367454 details
Gsk3bSmad3BioGRID18172167 details
Gsk3bPrkczBioGRID16510873 17053159 details
Gsk3bCtnnd2BioGRID20623542 details
Gsk3bCops2BioGRID19576224 details
Gsk3bMdm2BioGRID21738215 details
Gsk3bTrp53BioGRID21738215 details
Gsk3bIkbkgBioGRID12808104 details
Gsk3bPlekho1BioGRID24777252 details
Gsk3bMap3k4BioGRID17726008 details
Gsk3bTlr3BioGRID25828701 details
Gsk3bTraf6BioGRID25828701 details
Gsk3bMap3k7BioGRID25828701 details
Gsk3bTab1BioGRID25828701 details
Gsk3bTab2BioGRID25828701 details
Gsk3bTicam2BioGRID25828701 details
Gsk3bSnai1BioGRID28892081 details
Gsk3bCdk5r1BioGRID25331900 details
Gsk3bGrin1IntAct16635246 details
Gsk3bGrin2bIntAct16635246 details
Gsk3bARRB2IntAct16051150 details
Gsk3bLrrk2BioGRID, IntAct22899650 details
Gsk3bZER1BioGRID, IntAct26496610 details
Gsk3bTAF5BioGRID, IntAct26496610 details
Gsk3bREPS2BioGRID, IntAct26496610 details
Gsk3bAXIN1BioGRID, IntAct26496610 details
Gsk3bMPZL1BioGRID, IntAct26496610 details
Gsk3bSLCO4A1BioGRID, IntAct26496610 details
Gsk3bCDCA7LBioGRID, IntAct26496610 details
Gsk3bNUDT18BioGRID, IntAct26496610 details
Gsk3bTFAP2ABioGRID, IntAct26496610 details
Gsk3bSBSNBioGRID, IntAct26496610 details
Gsk3bNDUFV3BioGRID, IntAct26496610 details
Gsk3bNT5DC3BioGRID, IntAct26496610 details
Gsk3bEPB41L4BBioGRID, IntAct26496610 details
Gsk3bPRKACBBioGRID, IntAct26496610 details
Gsk3bSHARPINBioGRID, IntAct26496610 details
Gsk3bRAB11FIP2BioGRID, IntAct26496610 details
Gsk3bMTRRBioGRID, IntAct26496610 details
Gsk3bZNF273BioGRID, IntAct26496610 details
Gsk3bRBM26BioGRID, IntAct26496610 details
Gsk3bBCORBioGRID, IntAct26496610 details
Gsk3bPRKAR1ABioGRID, IntAct26496610 details
Gsk3bAPCBioGRID, IntAct26496610 details
Gsk3bPOLR1GBioGRID, IntAct26496610 details
Gsk3bPSEN1IntAct27036734 details
Gsk3bCyfip1BioGRID, IntAct28671696 details
Gsk3bFxr1BioGRID, IntAct28671696 details
Gsk3bHcn1BioGRID, IntAct28671696 details
Gsk3bNckap1BioGRID, IntAct28671696 details
Gsk3bTnikBioGRID, IntAct28671696 details
Gsk3bShank3BioGRID, IntAct, MINT27507650 28671696 29111324 details
Gsk3bAgap2BioGRID, IntAct28706196 details
Gsk3bSyngap1BioGRID, IntAct28706196 details
Gsk3bFoxp3BioGRID22922362 details
Gsk3bEedBioGRID24457600 details
Gsk3bZCCHC14BioGRID26496610 details
Gsk3bSYNPO2BioGRID26496610 details
Gsk3bWdtc1BioGRID27113764 details
Gsk3bAtxn1BioGRID30457570 details
Gsk3bPpp1caBioGRID29669786 details
Gsk3bAtpif1BioGRID32325033 details
Gsk3bCsadBioGRID32325033 details
Gsk3bNat9BioGRID32325033 details
Gsk3bPkmBioGRID32325033 details
Gsk3bPpp1r2BioGRID32325033 details
Gsk3bPrps2BioGRID32325033 details
Gsk3bDctn3BioGRID32325033 details
Gsk3bGipc1BioGRID32325033 details
Gsk3bAcsbg1BioGRID32325033 details
Gsk3bCamsap3BioGRID32325033 details
Gsk3bClasp2BioGRID32325033 details
Gsk3bDnm1lBioGRID32325033 details
Gsk3bEif2b5BioGRID32325033 details
Gsk3bEif4ebp1BioGRID32325033 details
Gsk3bFermt2BioGRID32325033 details
Gsk3bFibpBioGRID32325033 details
Gsk3bGsk3aBioGRID32325033 details
Gsk3bHsp90aa1BioGRID32325033 details
Gsk3bHtra2BioGRID32325033 details
Gsk3b4833439L19RikBioGRID32325033 details
Gsk3bPrune1BioGRID32325033 details
Gsk3bTpppBioGRID32325033 details
Gsk3bGys1BioGRID32325033 details
Gsk3bGskipBioGRID32325033 details
Gsk3bSlc6a4BioGRID32581705 details