Entity Details

Primary name Park7
Entity type gene
Source Source Link

Details

PrimaryID57320
RefseqGene
SymbolPark7
NameParkinson disease (autosomal recessive, early onset) 7
Chromosome4
Location4
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-09
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsPARK7_MOUSE

GO terms

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GOName
GO:0000785 chromatin
GO:0001933 negative regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005102 signaling receptor binding
GO:0005507 copper ion binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006281 DNA repair
GO:0006469 negative regulation of protein kinase activity
GO:0006517 protein deglycosylation
GO:0006914 autophagy
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0007338 single fertilization
GO:0008134 transcription factor binding
GO:0008233 peptidase activity
GO:0008344 adult locomotory behavior
GO:0010273 detoxification of copper ion
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016532 superoxide dismutase copper chaperone activity
GO:0016570 histone modification
GO:0016605 PML body
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019249 lactate biosynthetic process
GO:0019826 oxygen sensor activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019955 cytokine binding
GO:0030073 insulin secretion
GO:0030424 axon
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032757 positive regulation of interleukin-8 production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033182 regulation of histone ubiquitination
GO:0033234 negative regulation of protein sumoylation
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0035065 regulation of histone acetylation
GO:0036470 tyrosine 3-monooxygenase activator activity
GO:0036471 cellular response to glyoxal
GO:0036478 L-dopa decarboxylase activator activity
GO:0036524 protein deglycase activity
GO:0036526 peptidyl-cysteine deglycation
GO:0036527 peptidyl-arginine deglycation
GO:0036528 peptidyl-lysine deglycation
GO:0036529 protein deglycation, glyoxal removal
GO:0036530 protein deglycation, methylglyoxal removal
GO:0036531 glutathione deglycation
GO:0042177 negative regulation of protein catabolic process
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042743 hydrogen peroxide metabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044297 cell body
GO:0044388 small protein activating enzyme binding
GO:0044390 ubiquitin-like protein conjugating enzyme binding
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045340 mercury ion binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046295 glycolate biosynthetic process
GO:0046826 negative regulation of protein export from nucleus
GO:0048471 perinuclear region of cytoplasm
GO:0050681 androgen receptor binding
GO:0050727 regulation of inflammatory response
GO:0050787 detoxification of mercury ion
GO:0050821 protein stabilization
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051881 regulation of mitochondrial membrane potential
GO:0051899 membrane depolarization
GO:0051920 peroxiredoxin activity
GO:0060081 membrane hyperpolarization
GO:0060548 negative regulation of cell death
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061727 methylglyoxal catabolic process to lactate
GO:0061827 sperm head
GO:0070301 cellular response to hydrogen peroxide
GO:0070994 detection of oxidative stress
GO:0097110 scaffold protein binding
GO:0098793 presynapse
GO:0106044 guanine deglycation
GO:0106045 guanine deglycation, methylglyoxal removal
GO:0106046 guanine deglycation, glyoxal removal
GO:0110095 cellular detoxification of aldehyde
GO:0140041 cellular detoxification of methylglyoxal
GO:1900182 positive regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death
GO:1901671 positive regulation of superoxide dismutase activity
GO:1901984 negative regulation of protein acetylation
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902958 positive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903094 negative regulation of protein K48-linked deubiquitination
GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway
GO:1903135 cupric ion binding
GO:1903136 cuprous ion binding
GO:1903168 positive regulation of pyrroline-5-carboxylate reductase activity
GO:1903178 positive regulation of tyrosine 3-monooxygenase activity
GO:1903181 positive regulation of dopamine biosynthetic process
GO:1903189 glyoxal metabolic process
GO:1903197 positive regulation of L-dopa biosynthetic process
GO:1903200 positive regulation of L-dopa decarboxylase activity
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903384 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904782 negative regulation of NMDA glutamate receptor activity
GO:1905259 negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
GO:1905516 positive regulation of fertilization
GO:1990381 ubiquitin-specific protease binding
GO:1990422 glyoxalase (glycolic acid-forming) activity
GO:2000157 negative regulation of ubiquitin-specific protease activity
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000825 positive regulation of androgen receptor activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Diseases

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Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
Park7SypBioGRID21645620 details
Park7AppBioGRID27325702 details
Park7Rack1IntAct24947010 details
Park7Hdgfl2IntAct29128334 details
Park7Map3k5BioGRID17331951 details
Park7Rab7bBioGRID21645620 details
Park7Rab5bBioGRID21645620 details
Park7Rab4aBioGRID21645620 details
Park7Rab3aBioGRID21645620 details
Park7Vamp2BioGRID21645620 details
Park7Srebf2BioGRID22666465 details
Park7Trp53BioGRID19680261 details
Park7TncBioGRID19885556 details
Park7Hspa9BioGRID31767755 details
Park7Itpr3BioGRID31767755 details
Park7Vdac1BioGRID31767755 details
Park7PrkacaBioGRID31353306 details
Park7Kcnma1BioGRID, IntAct19423573 details
Park7Atp6v1aIntAct22707207 details
Park7Pag1IntAct26512138 details
Park7Cnksr2BioGRID, IntAct28671696 details
Park7Dlg4BioGRID, IntAct27507650 28671696 details
Park7NfkbieIntAct29128334 details
Park7DldIntAct29128334 details
Park7Rnps1IntAct29128334 details
Park7YwhazIntAct29128334 details
Park7YwhaqIntAct29128334 details
Park7YwhabIntAct29128334 details
Park7Tpm3IntAct29128334 details
Park7Tmod2IntAct29128334 details
Park7PdhbIntAct29128334 details
Park7Eef2IntAct29128334 details
Park7Dbn1IntAct29128334 details
Park7ChtopIntAct29128334 details
Park7Bclaf1IntAct29128334 details
Park7Actn1IntAct29128334 details
Park7Tcf3BioGRID22354994 details
Park7Foxp3BioGRID22922362 details
Park7Fancd2BioGRID28378742 details
Park7Ppp1r9bBioGRID30562941 details
Park7Tfe3BioGRID30595499 details
Park7Ndufa8BioGRID32325033 details
Park7Ndufa10BioGRID32325033 details
Park7Ndufa2BioGRID32325033 details
Park7Ndufa5BioGRID32325033 details
Park7Ndufab1BioGRID32325033 details
Park7Ndufb10BioGRID32325033 details
Park7Ndufb7BioGRID32325033 details
Park7Ndufs3BioGRID32325033 details
Park7Ndufs4BioGRID32325033 details
Park7Ndufs5BioGRID32325033 details
Park7Ndufs7BioGRID32325033 details
Park7Ndufv2BioGRID32325033 details
Park7Bcl2l1BioGRID32325033 details
Park7CstbBioGRID32325033 details
Park7Ndufa4BioGRID32325033 details
Park7Ndufv1BioGRID32325033 details
Park7Ndufv3BioGRID32325033 details
Park7Sod1BioGRID32325033 details
Park7Ndufa6BioGRID32325033 details
Park7Ndufb5BioGRID32325033 details
Park7Ndufa12BioGRID32325033 details
Park7Ndufb6BioGRID32325033 details
Park7UnkBioGRID25737280 details