Entity Details

Primary name Tsc1
Entity type gene
Source Source Link

Details

PrimaryID64930
RefseqGene
SymbolTsc1
NameTSC complex subunit 1
Chromosome2
Location2
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-24
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsTSC1_MOUSE

GO terms

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GOName
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0001952 regulation of cell-matrix adhesion
GO:0002250 adaptive immune response
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005938 cell cortex
GO:0006407 rRNA export from nucleus
GO:0006417 regulation of translation
GO:0006813 potassium ion transport
GO:0007160 cell-matrix adhesion
GO:0007399 nervous system development
GO:0008285 negative regulation of cell population proliferation
GO:0008344 adult locomotory behavior
GO:0010977 negative regulation of neuron projection development
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0017148 negative regulation of translation
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0030027 lamellipodium
GO:0030030 cell projection organization
GO:0030426 growth cone
GO:0030544 Hsp70 protein binding
GO:0032007 negative regulation of TOR signaling
GO:0032780 negative regulation of ATPase activity
GO:0032794 GTPase activating protein binding
GO:0032868 response to insulin
GO:0032991 protein-containing complex
GO:0033596 TSC1-TSC2 complex
GO:0034260 negative regulation of GTPase activity
GO:0042030 ATPase inhibitor activity
GO:0042552 myelination
GO:0042995 cell projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043379 memory T cell differentiation
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044877 protein-containing complex binding
GO:0045792 negative regulation of cell size
GO:0045859 regulation of protein kinase activity
GO:0046323 glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0047485 protein N-terminus binding
GO:0048471 perinuclear region of cytoplasm
GO:0050808 synapse organization
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0051492 regulation of stress fiber assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051726 regulation of cell cycle
GO:0051879 Hsp90 protein binding
GO:0051893 regulation of focal adhesion assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0055007 cardiac muscle cell differentiation
GO:0090630 activation of GTPase activity
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0101031 chaperone complex
GO:1901214 regulation of neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death

Diseases

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Interactions

128 interactions

InteractorPartnerSourcesPublicationsLink
Tsc1Ppp1caBioGRID, IntAct17274640 29669786 details
Tsc1RdxBioGRID10806479 details
Tsc1EzrBioGRID10806479 details
Tsc1EZRBioGRID10806479 details
Tsc1MsnBioGRID10806479 details
Tsc1YwhabMINT20412061 details
Tsc1Shank1MINT21653829 details
Tsc1Bex3BioGRID17355907 details
Tsc1Usp1BioGRID32133736 details
Tsc1Wdr48BioGRID32133736 details
Tsc1Phlpp1BioGRID32133736 details
Tsc1Akt1BioGRID32133736 details
Tsc1USP1BioGRID32133736 details
Tsc1Dab2BioGRID32133736 details
Tsc1Rps6kb1MINT20412061 details
Tsc1RhebMINT20412061 details
Tsc1LETMD1BioGRID, IntAct26496610 details
Tsc1SLU7BioGRID, IntAct26496610 details
Tsc1DYNC1I2BioGRID, IntAct26496610 details
Tsc1CCAR1BioGRID, IntAct26496610 details
Tsc1SFPQBioGRID, IntAct26496610 details
Tsc1JAK1BioGRID, IntAct26496610 details
Tsc1TSC2BioGRID, IntAct26496610 details
Tsc1ANO3BioGRID, IntAct26496610 details
Tsc1MRPS9BioGRID, IntAct26496610 details
Tsc1SGF29BioGRID, IntAct26496610 details
Tsc1PDFBioGRID, IntAct26496610 details
Tsc1PYGBBioGRID, IntAct26496610 details
Tsc1ZNF3BioGRID, IntAct26496610 details
Tsc1EIF4ENIF1BioGRID, IntAct26496610 details
Tsc1DAP3BioGRID, IntAct26496610 details
Tsc1DNM2BioGRID, IntAct26496610 details
Tsc1ZBED6BioGRID, IntAct26496610 details
Tsc1Nckap1BioGRID, IntAct28671696 details
Tsc1Hsp90ab1BioGRID, IntAct28671696 details
Tsc1Tmed10BioGRID, IntAct28671696 details
Tsc1Tdrd3BioGRID, IntAct28671696 details
Tsc1Ppp2cbBioGRID, IntAct28671696 details
Tsc1Lamtor1BioGRID, IntAct28671696 details
Tsc1Fxr1BioGRID, IntAct28671696 details
Tsc1Celsr2BioGRID, IntAct28671696 details
Tsc1Ampd2BioGRID, IntAct28671696 details
Tsc1Arhgap32BioGRID, IntAct28671696 details
Tsc1TnikBioGRID, IntAct28671696 details
Tsc1Rab7BioGRID, IntAct28671696 details
Tsc1CyribBioGRID, IntAct28671696 details
Tsc1Dnaja4BioGRID, IntAct28671696 details
Tsc1YwhaqBioGRID, IntAct28671696 details
Tsc1Wnk3BioGRID, IntAct28671696 details
Tsc1Wnk2BioGRID, IntAct28671696 details
Tsc1Usp9xBioGRID, IntAct28671696 details
Tsc1Trim28BioGRID, IntAct28671696 details
Tsc1Trp53bp1BioGRID, IntAct28671696 details
Tsc1TnksBioGRID, IntAct28671696 details
Tsc1Tmed9BioGRID, IntAct28671696 details
Tsc1Soga3BioGRID, IntAct28671696 details
Tsc1Smc2BioGRID, IntAct28671696 details
Tsc1SfpqBioGRID, IntAct28671696 details
Tsc1Sestd1BioGRID, IntAct28671696 details
Tsc1ScribBioGRID, IntAct28671696 details
Tsc1PtprsBioGRID, IntAct28671696 details
Tsc1Pak5BioGRID, IntAct28671696 details
Tsc1NischBioGRID, IntAct28671696 details
Tsc1Nedd4BioGRID, IntAct28671696 details
Tsc1NcanBioGRID, IntAct28671696 details
Tsc1Matr3BioGRID, IntAct28671696 details
Tsc1Maged1BioGRID, IntAct28671696 details
Tsc1Kif5cBioGRID, IntAct28671696 details
Tsc1Kdm1aBioGRID, IntAct28671696 details
Tsc1Igf2rBioGRID, IntAct28671696 details
Tsc1Hspa8BioGRID, IntAct28671696 details
Tsc1Hsp90aa1BioGRID, IntAct28671696 details
Tsc1Foxg1BioGRID, IntAct28671696 details
Tsc1Tcaf1BioGRID, IntAct28671696 details
Tsc1Epha4BioGRID, IntAct28671696 details
Tsc1Eif4a2BioGRID, IntAct28671696 details
Tsc1Eef2BioGRID, IntAct28671696 details
Tsc1Dyrk1aBioGRID, IntAct28671696 details
Tsc1DcxBioGRID, IntAct28671696 details
Tsc1Clasp1BioGRID, IntAct28671696 details
Tsc1Cct8BioGRID, IntAct28671696 details
Tsc1Cct3BioGRID, IntAct28671696 details
Tsc1CadBioGRID, IntAct28671696 details
Tsc1Syngap1BioGRID, IntAct28671696 details
Tsc1Shank3BioGRID, IntAct28671696 details
Tsc1Ppp3caBioGRID, IntAct28671696 details
Tsc1Mink1BioGRID, IntAct28671696 details
Tsc1Dlg4BioGRID, IntAct28671696 details
Tsc1Cyfip1BioGRID, IntAct28671696 details
Tsc1Camk2gBioGRID, IntAct28671696 details
Tsc1Camk2dBioGRID, IntAct28671696 details
Tsc1Camk2bBioGRID, IntAct28671696 details
Tsc1Arhgef2BioGRID, IntAct28671696 details
Tsc1Appl1BioGRID, IntAct28671696 details
Tsc1Abi1BioGRID, IntAct28671696 details
Tsc1YwhazBioGRID, IntAct28671696 details
Tsc1Wasf1BioGRID, IntAct28671696 details
Tsc1Trim3BioGRID, IntAct28671696 details
Tsc1TnrBioGRID, IntAct28671696 details
Tsc1Tbc1d7BioGRID, IntAct28671696 details
Tsc1Sec23aBioGRID, IntAct28671696 details
Tsc1Rasal1BioGRID, IntAct28671696 details
Tsc1Rap2bBioGRID, IntAct28671696 details
Tsc1RanBioGRID, IntAct28671696 details
Tsc1Rac1BioGRID, IntAct28671696 details
Tsc1Rab14BioGRID, IntAct28671696 details
Tsc1PuraBioGRID, IntAct28671696 details
Tsc1PrkcgBioGRID, IntAct28671696 details
Tsc1PrkcbBioGRID, IntAct28671696 details
Tsc1Lgi1BioGRID, IntAct28671696 details
Tsc1KrasBioGRID, IntAct28671696 details
Tsc1HrasBioGRID, IntAct28671696 details
Tsc1Rack1BioGRID, IntAct28671696 details
Tsc1Fbxo41BioGRID, IntAct28671696 details
Tsc1Dnaja2BioGRID, IntAct28671696 details
Tsc1Dnaja1BioGRID, IntAct28671696 details
Tsc1Cyfip2BioGRID, IntAct28671696 details
Tsc1Cul3BioGRID, IntAct28671696 details
Tsc1Ctnnb1BioGRID, IntAct28671696 details
Tsc1Cnrip1BioGRID, IntAct28671696 details
Tsc1Cdk5BioGRID, IntAct28671696 details
Tsc1Camk2aBioGRID, IntAct28671696 details
Tsc1Actn1MINT21653829 details
Tsc1YwhaeBioGRID16944949 details
Tsc1TBC1D7BioGRID26496610 details
Tsc1Ccnb1BioGRID32325033 details
Tsc1Pih1d1BioGRID32325033 details
Tsc1Foxo3BioGRID32133736 details