Entity Details

Primary name Vps35
Entity type gene
Source Source Link

Details

PrimaryID65114
RefseqGene
SymbolVps35
NameVPS35 retromer complex component
Chromosome8
Location8 41.61 cM
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-31
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsVPS35_MOUSE

GO terms

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GOName
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0006624 vacuolar protein processing
GO:0006886 intracellular protein transport
GO:0007040 lysosome organization
GO:0007416 synapse assembly
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030904 retromer complex
GO:0030906 retromer, cargo-selective complex
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0031748 D1 dopamine receptor binding
GO:0032268 regulation of cellular protein metabolic process
GO:0032456 endocytic recycling
GO:0032463 negative regulation of protein homooligomerization
GO:0033365 protein localization to organelle
GO:0036010 protein localization to endosome
GO:0042147 retrograde transport, endosome to Golgi
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045056 transcytosis
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0050728 negative regulation of inflammatory response
GO:0050882 voluntary musculoskeletal movement
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0060548 negative regulation of cell death
GO:0061357 positive regulation of Wnt protein secretion
GO:0090141 positive regulation of mitochondrial fission
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090326 positive regulation of locomotion involved in locomotory behavior
GO:0097422 tubular endosome
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
GO:0098978 glutamatergic synapse
GO:0099003 vesicle-mediated transport in synapse
GO:0099073 mitochondrion-derived vesicle
GO:0099074 mitochondrion to lysosome transport
GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane
GO:1901215 negative regulation of neuron death
GO:1902823 negative regulation of late endosome to lysosome transport
GO:1902950 regulation of dendritic spine maintenance
GO:1903181 positive regulation of dopamine biosynthetic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903828 negative regulation of cellular protein localization
GO:1905166 negative regulation of lysosomal protein catabolic process
GO:2000331 regulation of terminal button organization

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
Vps35Vps26aBioGRID, DIP, UniProt15965486 18656452 21040701 32325033 details
Vps35Vps29BioGRID, DIP, UniProt15965486 18656452 20923837 21040701 32325033 details
Vps35FKBP15BioGRID, UniProt20923837 24819384 details
Vps35WASHC2CUniProt20923837 details
Vps35Itga2bBioGRID30333137 details
Vps35LRRK2IntAct23395371 details
Vps35Lrrk2IntAct23395371 details
Vps35Vps26bBioGRID, UniProt18656452 21040701 32325033 details
Vps35Sort1DIP, UniProt18480253 21040701 details
Vps35VPS26ABioGRID, UniProt20923837 24819384 details
Vps35VPS29BioGRID, UniProt20923837 24819384 details
Vps35WASHC5BioGRID, UniProt20923837 24819384 details
Vps35WASHC1BioGRID, UniProt20923837 24819384 details
Vps35Sorl1DIP18480253 details
Vps35Snx1BioGRID18656452 32325033 details
Vps35ATG9ABioGRID24819384 details
Vps35YwhabIntAct16635246 details
Vps35YwhazIntAct19562802 details
Vps35VPS35UniProt20923837 details
Vps35CAPZA2UniProt20923837 details
Vps35WASHC2AUniProt20923837 details
Vps35CAPZBUniProt20923837 details
Vps35TBC1D5UniProt20923837 details
Vps35WASHC4UniProt20923837 details
Vps35CAPZA1UniProt20923837 details
Vps35VPS26BUniProt20923837 details
Vps35Rab5cIntAct26885862 details
Vps35Rab17IntAct26885862 details
Vps35Rab4aIntAct26885862 details
Vps35Rab1aIntAct26885862 details
Vps35Rab3aIntAct26885862 details
Vps35Rab4bIntAct26885862 details
Vps35Rab32IntAct26885862 details
Vps35Pag1IntAct26512138 details
Vps35Xpo7IntAct29748336 unassigned1673 details
Vps35EedBioGRID24457600 details
Vps35Fancd2BioGRID28378742 details
Vps35Atxn1BioGRID30457570 details
Vps35MaptBioGRID30068389 details
Vps35Dctn1BioGRID32325033 details
Vps35Micall1BioGRID32325033 details
Vps35Atp6v1c1BioGRID32325033 details
Vps35Plxdc2BioGRID32325033 details
Vps35PsapBioGRID32325033 details
Vps35Rab7BioGRID32325033 details
Vps35Snx2BioGRID32325033 details
Vps35Snx6BioGRID32325033 details
Vps35Ankfy1BioGRID32325033 details
Vps35Tbc1d5BioGRID32325033 details
Vps35CfdBioGRID30550785 details
Vps35Fndc5BioGRID30550785 details
Vps35UnkBioGRID25737280 details