Entity Details

Primary name Lrrk2
Entity type gene
Source Source Link

Details

PrimaryID66725
RefseqGene
SymbolLrrk2
Nameleucine-rich repeat kinase 2
Chromosome15
Location15
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-02-20
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsLRRK2_MOUSE

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000149 SNARE binding
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000287 magnesium ion binding
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005096 GTPase activator activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007040 lysosome organization
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007528 neuromuscular junction development
GO:0008021 synaptic vesicle
GO:0008340 determination of adult lifespan
GO:0009267 cellular response to starvation
GO:0010468 regulation of gene expression
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010738 regulation of protein kinase A signaling
GO:0010955 negative regulation of protein processing
GO:0010977 negative regulation of neuron projection development
GO:0014041 regulation of neuron maturation
GO:0015631 tubulin binding
GO:0016020 membrane
GO:0016234 inclusion body
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0017075 syntaxin-1 binding
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0021756 striatum development
GO:0021772 olfactory bulb development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0030159 signaling receptor complex adaptor activity
GO:0030276 clathrin binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030672 synaptic vesicle membrane
GO:0031267 small GTPase binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031647 regulation of protein stability
GO:0031966 mitochondrial membrane
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032839 dendrite cytoplasm
GO:0034211 GTP-dependent protein kinase activity
GO:0034260 negative regulation of GTPase activity
GO:0034599 cellular response to oxidative stress
GO:0034613 cellular protein localization
GO:0035556 intracellular signal transduction
GO:0035564 regulation of kidney size
GO:0035640 exploration behavior
GO:0035641 locomotory exploration behavior
GO:0035751 regulation of lysosomal lumen pH
GO:0036465 synaptic vesicle recycling
GO:0036479 peroxidase inhibitor activity
GO:0040012 regulation of locomotion
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043068 positive regulation of programmed cell death
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0044325 transmembrane transporter binding
GO:0044753 amphisome
GO:0044754 autolysosome
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045202 synapse
GO:0046039 GTP metabolic process
GO:0046777 protein autophosphorylation
GO:0048312 intracellular distribution of mitochondria
GO:0048812 neuron projection morphogenesis
GO:0051018 protein kinase A binding
GO:0051646 mitochondrion localization
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051900 regulation of mitochondrial depolarization
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060079 excitatory postsynaptic potential
GO:0060159 regulation of dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0060628 regulation of ER to Golgi vesicle-mediated transport
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070971 endoplasmic reticulum exit site
GO:0070973 protein localization to endoplasmic reticulum exit site
GO:0070997 neuron death
GO:0071287 cellular response to manganese ion
GO:0071407 cellular response to organic cyclic compound
GO:0072593 reactive oxygen species metabolic process
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:0097487 multivesicular body, internal vesicle
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099400 caveola neck
GO:0099523 presynaptic cytosol
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0140058 neuron projection arborization
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1900244 positive regulation of synaptic vesicle endocytosis
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901727 positive regulation of histone deacetylase activity
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902499 positive regulation of protein autoubiquitination
GO:1902692 regulation of neuroblast proliferation
GO:1902803 regulation of synaptic vesicle transport
GO:1902902 negative regulation of autophagosome assembly
GO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903215 negative regulation of protein targeting to mitochondrion
GO:1903351 cellular response to dopamine
GO:1903980 positive regulation of microglial cell activation
GO:1904713 beta-catenin destruction complex binding
GO:1904887 Wnt signalosome assembly
GO:1905279 regulation of retrograde transport, endosome to Golgi
GO:1905289 regulation of CAMKK-AMPK signaling cascade
GO:1990904 ribonucleoprotein complex
GO:1990909 Wnt signalosome
GO:2000172 regulation of branching morphogenesis of a nerve
GO:2000300 regulation of synaptic vesicle exocytosis

Diseases

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Interactions

96 interactions

InteractorPartnerSourcesPublicationsLink
Lrrk2Lrrk2BioGRID, IntAct17623048 20659021 21390248 22952686 27357661 details
Lrrk2PrkacaIntAct21390248 details
Lrrk2MSNIntAct24794857 details
Lrrk2Taok1BioGRID20949042 details
Lrrk2MbpBioGRID17623048 details
Lrrk2Actr2BioGRID, IntAct20876399 25926623 details
Lrrk2NsfIntAct21307259 24687852 details
Lrrk2Arfgap1IntAct22363216 details
Lrrk2Dnm1lBioGRID, IntAct22639965 24282027 29541021 details
Lrrk2Dvl1IntAct22899650 details
Lrrk2SncaIntAct23183827 details
Lrrk2YwhagBioGRID, IntAct21390248 31046837 details
Lrrk2YwhazBioGRID, IntAct21390248 31046837 details
Lrrk2YwhabBioGRID, IntAct21390248 31046837 details
Lrrk2YwhaqBioGRID, IntAct20642453 20659021 21390248 31046837 details
Lrrk2YwhaeBioGRID, IntAct21390248 31046837 details
Lrrk2YwhahBioGRID, IntAct21390248 31046837 details
Lrrk2Cdc42BioGRID, IntAct21048939 details
Lrrk2Arhgef7BioGRID, IntAct21048939 details
Lrrk2FaddIntAct19176810 details
Lrrk2Vps35IntAct23395371 details
Lrrk2Prkar2bIntAct24464040 details
Lrrk2Rgs2IntAct24794857 details
Lrrk2RAB32IntAct25360523 details
Lrrk2Sec16aIntAct25201882 details
Lrrk2Wsb1BioGRID, IntAct27273569 details
Lrrk2Stub1BioGRID, DIP19196961 details
Lrrk2Atp2a2IntAct31046837 details
Lrrk2Ripk2BioGRID20949042 details
Lrrk2Hsp90aa1BioGRID18367605 20642453 details
Lrrk2Cdc37BioGRID18367605 details
Lrrk2Tubb4aBioGRID19545277 details
Lrrk2Fis1BioGRID22639965 details
Lrrk2Rab5bBioGRID18445495 details
Lrrk2Herc2BioGRID26355680 details
Lrrk2Neurl4BioGRID26355680 details
Lrrk2Ripk1BioGRID29891719 details
Lrrk2Cdk5BioGRID26268594 details
Lrrk2MaptBioGRID26268594 details
Lrrk2Pak6BioGRID26375402 details
Lrrk2Myh9BioGRID25926623 details
Lrrk2Arpc3BioGRID25926623 details
Lrrk2Rac1BioGRID25926623 details
Lrrk2Gnai2IntAct20876399 details
Lrrk2Myo1cIntAct20876399 details
Lrrk2Mpc2IntAct20876399 details
Lrrk2Myo1dIntAct20876399 details
Lrrk2Atp5lIntAct20876399 details
Lrrk2Ppp1r12aIntAct20876399 details
Lrrk2Myl6IntAct20876399 details
Lrrk2MpripIntAct20876399 details
Lrrk2Calm1IntAct20876399 details
Lrrk2Calm2IntAct20876399 details
Lrrk2Calm3IntAct20876399 details
Lrrk2Myl12bIntAct20876399 details
Lrrk2Myo1bIntAct20876399 details
Lrrk2Capza2IntAct20876399 details
Lrrk2Rai14IntAct20876399 details
Lrrk2ActbIntAct20876399 24687852 details
Lrrk2Tmod3IntAct20876399 details
Lrrk2Tpm3IntAct20876399 details
Lrrk2Arpc5IntAct20876399 details
Lrrk2Actbl2IntAct20876399 details
Lrrk2CapzbIntAct20876399 details
Lrrk2Arpc1bIntAct20876399 details
Lrrk2Actg1IntAct20876399 details
Lrrk2Arpc2IntAct20876399 details
Lrrk2Arpc4IntAct20876399 details
Lrrk2Actr3IntAct20876399 details
Lrrk2PlecIntAct20876399 details
Lrrk2Tpm2IntAct20876399 details
Lrrk2Tpm1IntAct20876399 details
Lrrk2Dbn1IntAct20876399 details
Lrrk2Lima1IntAct20876399 details
Lrrk2Dvl3BioGRID, IntAct22899650 details
Lrrk2Gsk3bBioGRID, IntAct22899650 details
Lrrk2Ctnnb1BioGRID, IntAct22899650 details
Lrrk2Axin1BioGRID, IntAct22899650 details
Lrrk2LRRK2IntAct24687852 26894577 details
Lrrk2Stxbp1IntAct24687852 details
Lrrk2Dnm1IntAct24282027 24687852 details
Lrrk2Vamp2IntAct24687852 details
Lrrk2Stx1aIntAct24687852 details
Lrrk2Opa1IntAct24282027 details
Lrrk2Bag5BioGRID, IntAct24510904 details
Lrrk2RGS2IntAct24794857 details
Lrrk2Tmx1IntAct31046837 details
Lrrk2CalrIntAct31046837 details
Lrrk2Erlin1IntAct31046837 details
Lrrk2P4hbIntAct31046837 details
Lrrk2Hsp90b1IntAct31046837 details
Lrrk2Hspa5IntAct31046837 details
Lrrk2CptpBioGRID32325033 details
Lrrk2Gpbp1l1BioGRID32325033 details
Lrrk2Dnaja1BioGRID32325033 details
Lrrk2Wipf1BioGRID32325033 details