Entity Details

Primary name PEN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9CQR7
EntryNamePEN2_MOUSE
FullNameGamma-secretase subunit PEN-2
TaxID10090
Evidenceevidence at protein level
Length101
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesPsenen

GO terms

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GOName
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0010950 positive regulation of endopeptidase activity
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0032580 Golgi cisterna membrane
GO:0034205 amyloid-beta formation
GO:0042982 amyloid precursor protein metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0043085 positive regulation of catalytic activity
GO:0061133 endopeptidase activator activity
GO:0070765 gamma-secretase complex
GO:0099056 integral component of presynaptic membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Golgi apparatus
Membrane

Domains

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DomainNameCategoryType
IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunitFamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PEN2_MOUSETMED2_MOUSEIntAct16641999 details
PEN2_MOUSEPSN2_MOUSEBioGRID15474363 details