Entity Details

Primary name DHX9_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO70133
EntryNameDHX9_MOUSE
FullNameATP-dependent RNA helicase A
TaxID10090
Evidenceevidence at protein level
Length1380
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesDhx9

GO terms

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GOName
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000993 RNA polymerase II complex binding
GO:0001069 regulatory region RNA binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005726 perichromatin fibrils
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005844 polysome
GO:0006353 DNA-templated transcription, termination
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006954 inflammatory response
GO:0007623 circadian rhythm
GO:0010501 RNA secondary structure unwinding
GO:0015629 actin cytoskeleton
GO:0016442 RISC complex
GO:0016604 nuclear body
GO:0016887 ATP hydrolysis activity
GO:0017111 nucleoside-triphosphatase activity
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0031490 chromatin DNA binding
GO:0032508 DNA duplex unwinding
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032741 positive regulation of interleukin-18 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033679 3'-5' DNA/RNA helicase activity
GO:0034458 3'-5' RNA helicase activity
GO:0034605 cellular response to heat
GO:0034622 cellular protein-containing complex assembly
GO:0035197 siRNA binding
GO:0035613 RNA stem-loop binding
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0039695 DNA-templated viral transcription
GO:0042788 polysomal ribosome
GO:0043138 3'-5' DNA helicase activity
GO:0044806 G-quadruplex DNA unwinding
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045142 triplex DNA binding
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046833 positive regulation of RNA export from nucleus
GO:0046872 metal ion binding
GO:0047429 nucleoside-triphosphate diphosphatase activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0050434 positive regulation of viral transcription
GO:0050684 regulation of mRNA processing
GO:0050691 regulation of defense response to virus by host
GO:0050729 positive regulation of inflammatory response
GO:0051028 mRNA transport
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060760 positive regulation of response to cytokine stimulus
GO:0061676 importin-alpha family protein binding
GO:0070063 RNA polymerase binding
GO:0070269 pyroptosis
GO:0070578 RISC-loading complex
GO:0070922 small RNA loading onto RISC
GO:0070934 CRD-mediated mRNA stabilization
GO:0070937 CRD-mediated mRNA stability complex
GO:0071356 cellular response to tumor necrosis factor
GO:0071360 cellular response to exogenous dsRNA
GO:0097165 nuclear stress granule
GO:1903608 protein localization to cytoplasmic stress granule
GO:1904973 positive regulation of viral translation
GO:1905172 RISC complex binding
GO:1905538 polysome binding
GO:1905698 positive regulation of polysome binding
GO:1990518 single-stranded 3'-5' DNA helicase activity
GO:1990825 sequence-specific mRNA binding
GO:1990841 promoter-specific chromatin binding
GO:1990904 ribonucleoprotein complex
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:2000637 positive regulation of gene silencing by miRNA
GO:2000765 regulation of cytoplasmic translation
GO:2000767 positive regulation of cytoplasmic translation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved siteSiteConserved site
IPR007502 Helicase-associated domainDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR011709 Domain of unknown function DUF1605DomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR044445 DHX9, first double-stranded RNA binding domainDomainDomain
IPR044446 DHX9, second double-stranded RNA binding domainDomainDomain
IPR044447 DHX9, DEXH-box helicase domainDomainDomain

Diseases

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Interactions

3 interactions