Entity Details

Primary name SMUF1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9CUN6
EntryNameSMUF1_MOUSE
FullNameE3 ubiquitin-protein ligase SMURF1
TaxID10090
Evidenceevidence at protein level
Length731
SequenceStatuscomplete
DateCreated2001-12-13
DateModified2021-06-02

Ontological Relatives

GenesSmurf1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006611 protein export from nucleus
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030424 axon
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0032801 receptor catabolic process
GO:0034394 protein localization to cell surface
GO:0043025 neuronal cell body
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0061630 ubiquitin protein ligase activity
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0061736 engulfment of target by autophagosome
GO:0061753 substrate localization to autophagosome
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0071211 protein targeting to vacuole involved in autophagy
GO:1903861 positive regulation of dendrite extension
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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