Entity Details

Primary name Sirt1
Entity type gene
Source Source Link

Details

PrimaryID93759
RefseqGene
SymbolSirt1
Namesirtuin 1
Chromosome10
Location10
TaxID10090
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-07-16
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsSIR1_MOUSE

GO terms

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GOName
GO:0000012 single strand break repair
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000183 rDNA heterochromatin assembly
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0000731 DNA synthesis involved in DNA repair
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001650 fibrillar center
GO:0001678 cellular glucose homeostasis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002039 p53 binding
GO:0002821 positive regulation of adaptive immune response
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006476 protein deacetylation
GO:0006642 triglyceride mobilization
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007346 regulation of mitotic cell cycle
GO:0007517 muscle organ development
GO:0007623 circadian rhythm
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009267 cellular response to starvation
GO:0010460 positive regulation of heart rate
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010824 regulation of centrosome duplication
GO:0010875 positive regulation of cholesterol efflux
GO:0010883 regulation of lipid storage
GO:0010906 regulation of glucose metabolic process
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014858 positive regulation of skeletal muscle cell proliferation
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0016575 histone deacetylation
GO:0016605 PML body
GO:0017136 NAD-dependent histone deacetylase activity
GO:0018394 peptidyl-lysine acetylation
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030225 macrophage differentiation
GO:0030308 negative regulation of cell growth
GO:0030424 axon
GO:0030426 growth cone
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031393 negative regulation of prostaglandin biosynthetic process
GO:0031507 heterochromatin assembly
GO:0031648 protein destabilization
GO:0032007 negative regulation of TOR signaling
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0033210 leptin-mediated signaling pathway
GO:0033553 rDNA heterochromatin
GO:0033558 protein deacetylase activity
GO:0034391 regulation of smooth muscle cell apoptotic process
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035098 ESC/E(Z) complex
GO:0035356 cellular triglyceride homeostasis
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127 regulation of cell population proliferation
GO:0042326 negative regulation of phosphorylation
GO:0042393 histone binding
GO:0042542 response to hydrogen peroxide
GO:0042595 behavioral response to starvation
GO:0042632 cholesterol homeostasis
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043398 HLH domain binding
GO:0043422 protein kinase B binding
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044321 response to leptin
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045471 response to ethanol
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045739 positive regulation of DNA repair
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0050872 white fat cell differentiation
GO:0051019 mitogen-activated protein kinase binding
GO:0051097 negative regulation of helicase activity
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0051898 negative regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0060125 negative regulation of growth hormone secretion
GO:0060548 negative regulation of cell death
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060907 positive regulation of macrophage cytokine production
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070301 cellular response to hydrogen peroxide
GO:0070403 NAD+ binding
GO:0070829 heterochromatin maintenance
GO:0070857 regulation of bile acid biosynthetic process
GO:0070914 UV-damage excision repair
GO:0070932 histone H3 deacetylation
GO:0071356 cellular response to tumor necrosis factor
GO:0071441 negative regulation of histone H3-K14 acetylation
GO:0071456 cellular response to hypoxia
GO:0071479 cellular response to ionizing radiation
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0090312 positive regulation of protein deacetylation
GO:0090335 regulation of brown fat cell differentiation
GO:0090400 stress-induced premature senescence
GO:0097009 energy homeostasis
GO:0106230 protein depropionylation
GO:0106231 protein-propionyllysine depropionylase activity
GO:1900113 negative regulation of histone H3-K9 trimethylation
GO:1900181 negative regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1904179 positive regulation of adipose tissue development
GO:1904646 cellular response to amyloid-beta
GO:1990254 keratin filament binding
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990841 promoter-specific chromatin binding
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000614 positive regulation of thyroid-stimulating hormone secretion
GO:2000619 negative regulation of histone H4-K16 acetylation
GO:2000655 negative regulation of cellular response to testosterone stimulus
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2000773 negative regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
Sirt1ClockBioGRID, IntAct18662546 18662547 details
Sirt1Per2BioGRID, IntAct18662546 details
Sirt1CSNK2A1UniProt19680552 details
Sirt1TP53BioGRID, UniProt11672523 19680552 20167603 details
Sirt1FOXO1UniProt15220471 details
Sirt1RB1UniProt17620057 details
Sirt1EP300UniProt15632193 details
Sirt1Dyrk3BioGRID, UniProt20167603 details
Sirt1Dyrk1aBioGRID, UniProt20167603 details
Sirt1Ppargc1aBioGRID, UniProt15716268 15744310 details
Sirt1Hnf1aBioGRID, UniProt21176092 details
Sirt1PparaBioGRID, UniProt19356714 26443578 details
Sirt1Hoxb1BioGRID, IntAct20211142 details
Sirt1Nfe2BioGRID, IntAct20211142 details
Sirt1Cited4BioGRID, IntAct20211142 details
Sirt1Ncor2BioGRID15175761 details
Sirt1CSNK2A2BioGRID19680552 details
Sirt1DYRK1ABioGRID20167603 details
Sirt1DYRK3BioGRID20167603 details
Sirt1RxraBioGRID26443578 details
Sirt1ArntlBioGRID, IntAct18662546 18662547 details
Sirt1AcacaBioGRID, IntAct19343720 details
Sirt1Akt1IntAct21775285 details
Sirt1PMLUniProt12006491 details
Sirt1PmlUniProt12006491 details
Sirt1E2F1UniProt16892051 details
Sirt1RBL1UniProt17620057 details
Sirt1RBL2UniProt17620057 details
Sirt1HIC1UniProt16269335 details
Sirt1Hic1UniProt16269335 details
Sirt1PpargBioGRID, IntAct, UniProt15175761 22863012 details
Sirt1FOXO3UniProt15716268 details
Sirt1PPARGC1AUniProt15744310 details
Sirt1NR1I2UniProt21933665 details
Sirt1Irs1UniProt17901049 details
Sirt1Irs2UniProt17901049 details
Sirt1Srebf1UniProt20817729 details
Sirt1Smad7UniProt17098745 details
Sirt1STK11UniProt18687677 details
Sirt1Nr0b2BioGRID, UniProt20375098 21081708 details
Sirt1Snw1BioGRID, UniProt19934264 details
Sirt1Nhlh2IntAct22169038 details
Sirt1Bcl6IntAct25490446 details
Sirt1KMT2ADIP25751424 details
Sirt1Bcl11aBioGRID15639232 details
Sirt1RelaBioGRID21454709 details
Sirt1Ep300BioGRID21454709 details
Sirt1EsrraBioGRID20484414 details
Sirt1Nr1h4BioGRID19883617 details
Sirt1Trp53BioGRID20157588 details
Sirt1Pax3BioGRID21169561 details
Sirt1Kat8BioGRID22586264 details
Sirt1Kat5BioGRID22586264 details
Sirt1Mecp2BioGRID22677942 details
Sirt1JunBioGRID18676681 20042607 details
Sirt1FosBioGRID20042607 details
Sirt1JundBioGRID18676681 details
Sirt1IRS2BioGRID17901049 details
Sirt1Foxo1BioGRID22514318 details
Sirt1NdnBioGRID22514318 details
Sirt1Cbx5BioGRID28059589 details
Sirt1Obi1BioGRID32220064 details
Sirt1Rpgrip1lIntAct21565611 details
Sirt1Ccnb1UniProt19107194 details
Sirt1Cdk1UniProt19107194 details
Sirt1Hnf4aBioGRID, UniProt15744310 details
Sirt1RaraBioGRID, UniProt19934264 details
Sirt1Nr1h3UniProt17936707 details
Sirt1Nr1h2UniProt17936707 details
Sirt1BcorIntAct25490446 details
Sirt1Foxp3IntAct26365427 details
Sirt1Chaf1aBioGRID26365490 details
Sirt1DbpIntAct18662547 details
Sirt1MaoaIntAct22169038 details
Sirt1Gli2IntAct25490446 details
Sirt1Gli1IntAct25490446 details
Sirt1Hes5IntAct25490446 details
Sirt1Atoh1IntAct25490446 details
Sirt1Hes1BioGRID21169561 details
Sirt1Neurog2BioGRID21169561 details