Entity Details

Primary name ISL2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9CXV0
EntryNameISL2_MOUSE
FullNameInsulin gene enhancer protein ISL-2
TaxID10090
Evidenceevidence at protein level
Length359
SequenceStatuscomplete
DateCreated2002-05-15
DateModified2021-06-02

Ontological Relatives

GenesIsl2

GO terms

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GOName
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007409 axonogenesis
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021524 visceral motor neuron differentiation
GO:0031290 retinal ganglion cell axon guidance
GO:0045665 negative regulation of neuron differentiation
GO:0046872 metal ion binding
GO:0048663 neuron fate commitment
GO:0048665 neuron fate specification
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001781 Zinc finger, LIM-typeDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
ISL2_MOUSELDB1_MOUSEBioGRID, IntAct20211142 details
ISL2_MOUSELDB2_MOUSEBioGRID, IntAct20211142 details
ISL2_MOUSELHX4_MOUSEBioGRID, IntAct20211142 details
ISL2_MOUSESSBP2_MOUSEBioGRID, IntAct20211142 details
ISL2_MOUSESSBP3_MOUSEBioGRID, IntAct20211142 details
ISL2_MOUSEPYGO1_MOUSEBioGRID, IntAct20211142 details