Entity Details

Primary name CDK4
Entity type gene
Source Source Link

Details

PrimaryID1019
RefseqGeneNG_007484
SymbolCDK4
Namecyclin dependent kinase 4
Chromosome12
Location12q14.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-05
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsCDK4_HUMAN

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0002088 lens development in camera-type eye
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016592 mediator complex
GO:0030332 cyclin binding
GO:0030851 granulocyte differentiation
GO:0031100 animal organ regeneration
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045793 positive regulation of cell size
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046890 regulation of lipid biosynthetic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050994 regulation of lipid catabolic process
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0097129 cyclin D2-CDK4 complex
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904628 cellular response to phorbol 13-acetate 12-myristate
GO:1904637 cellular response to ionomycin
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CDK4Rb1BioGRID9840932 details
CDK4Cdkn1bDIP19276117 details
CDK4Kat2aDIP24870244 details
CDK4Sap25IntAct16449650 details