Entity Details

Primary name CHEK1
Entity type gene
Source Source Link

Details

PrimaryID1111
RefseqGeneNG_030049
SymbolCHEK1
Namecheckpoint kinase 1
Chromosome11
Location11q24.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-04-21
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsCHK1_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000785 chromatin
GO:0000794 condensed nuclear chromosome
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0018107 peptidyl-threonine phosphorylation
GO:0019904 protein domain specific binding
GO:0032991 protein-containing complex
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0035556 intracellular signal transduction
GO:0043231 intracellular membrane-bounded organelle
GO:0044818 mitotic G2/M transition checkpoint
GO:0045787 positive regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0046602 regulation of mitotic centrosome separation
GO:0048096 chromatin-mediated maintenance of transcription
GO:0070317 negative regulation of G0 to G1 transition
GO:0071260 cellular response to mechanical stimulus
GO:0090399 replicative senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:2000615 regulation of histone H3-K9 acetylation

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CHEK1Chek1BioGRID, IntAct20360068 details
CHEK1Cdk1BioGRID, IntAct26496610 details