Entity Details

Primary name TIRAP
Entity type gene
Source Source Link

Details

PrimaryID114609
RefseqGeneNG_011523
SymbolTIRAP
NameTIR domain containing adaptor protein
Chromosome11
Location11q24.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-09-13
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTIRAP_HUMAN

GO terms

Show/Hide Table
GOName
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005080 protein kinase C binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0030099 myeloid cell differentiation
GO:0030139 endocytic vesicle
GO:0030674 protein-macromolecule adaptor activity
GO:0030890 positive regulation of B cell proliferation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032496 response to lipopolysaccharide
GO:0032587 ruffle membrane
GO:0032648 regulation of interferon-beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032738 positive regulation of interleukin-15 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035662 Toll-like receptor 4 binding
GO:0035663 Toll-like receptor 2 binding
GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0090023 positive regulation of neutrophil chemotaxis
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Diseases

Show/Hide Table

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
TIRAPCapn1InnateDB23023391 details
TIRAPMyd88IntAct24529375 details
TIRAPIrak4IntAct24529375 details
TIRAPAgerIntAct21829704 details