Entity Details

Primary name CGAS
Entity type gene
Source Source Link

Details

PrimaryID115004
RefseqGene
SymbolCGAS
Namecyclic GMP-AMP synthase
Chromosome6
Location6q13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-10-04
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsCGAS_HUMAN

GO terms

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GOName
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002637 regulation of immunoglobulin production
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008340 determination of adult lifespan
GO:0010753 positive regulation of cGMP-mediated signaling
GO:0016032 viral process
GO:0032481 positive regulation of type I interferon production
GO:0035861 site of double-strand break
GO:0038001 paracrine signaling
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045087 innate immune response
GO:0046872 metal ion binding
GO:0050863 regulation of T cell activation
GO:0051607 defense response to virus
GO:0061501 cyclic-GMP-AMP synthase activity
GO:0071360 cellular response to exogenous dsRNA
GO:2000042 negative regulation of double-strand break repair via homologous recombination
GO:2000774 positive regulation of cellular senescence

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CGASTrim56BioGRID29426904 details
CGASEspl1BioGRID, IntAct26496610 details
CGASMus81BioGRID, IntAct26496610 details
CGASMecomMINT30462309 details