Entity Details

Primary name CYLD
Entity type gene
Source Source Link

Details

PrimaryID1540
RefseqGeneNG_012061
SymbolCYLD
NameCYLD lysine 63 deubiquitinase
Chromosome16
Location16q12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-05-21
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsCYLD_HUMAN

GO terms

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GOName
GO:0004843 thiol-dependent deubiquitinase
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008270 zinc ion binding
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016055 Wnt signaling pathway
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0036064 ciliary basal body
GO:0045087 innate immune response
GO:0046329 negative regulation of JNK cascade
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0060544 regulation of necroptotic process
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070064 proline-rich region binding
GO:0070266 necroptotic process
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070536 protein K63-linked deubiquitination
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097542 ciliary tip
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1902017 regulation of cilium assembly
GO:1903753 negative regulation of p38MAPK cascade
GO:1990108 protein linear deubiquitination
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
CYLDSpata2BioGRID27458237 details
CYLDLats2IntAct24255178 details
CYLDXpo1IntAct26673895 details