Entity Details

Primary name PRGC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO70343
EntryNamePRGC1_MOUSE
FullNamePeroxisome proliferator-activated receptor gamma coactivator 1-alpha
TaxID10090
Evidenceevidence at protein level
Length797
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesPpargc1a

GO terms

Show/Hide Table
GOName
GO:0000302 response to reactive oxygen species
GO:0000422 autophagy of mitochondrion
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0001933 negative regulation of protein phosphorylation
GO:0002021 response to dietary excess
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006012 galactose metabolic process
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0008209 androgen metabolic process
GO:0009409 response to cold
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0014732 skeletal muscle atrophy
GO:0014823 response to activity
GO:0014850 response to muscle activity
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016605 PML body
GO:0016922 nuclear receptor binding
GO:0019395 fatty acid oxidation
GO:0021549 cerebellum development
GO:0022626 cytosolic ribosome
GO:0022904 respiratory electron transport chain
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030900 forebrain development
GO:0031325 positive regulation of cellular metabolic process
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0035865 cellular response to potassium ion
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043014 alpha-tubulin binding
GO:0043025 neuronal cell body
GO:0043201 response to leucine
GO:0043231 intracellular membrane-bounded organelle
GO:0043524 negative regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051552 flavone metabolic process
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071250 cellular response to nitrite
GO:0071313 cellular response to caffeine
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071871 response to epinephrine
GO:0071873 response to norepinephrine
GO:0090258 negative regulation of mitochondrial fission
GO:0097009 energy homeostasis
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097440 apical dendrite
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901215 negative regulation of neuron death
GO:1901558 response to metformin
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:1904635 positive regulation of glomerular visceral epithelial cell apoptotic process
GO:1904637 cellular response to ionomycin
GO:1904639 cellular response to resveratrol
GO:1904640 response to methionine
GO:1990841 promoter-specific chromatin binding
GO:1990845 adaptive thermogenesis
GO:2000184 positive regulation of progesterone biosynthetic process
GO:2000272 negative regulation of signaling receptor activity
GO:2000310 regulation of NMDA receptor activity
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR034605 PGC-1FamilyFamily
IPR034625 Peroxisome proliferator-activated receptor gamma coactivator 1-alphaFamilyFamily
IPR034833 PGC-1alpha, RNA recognition motifDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table