Entity Details

Primary name DNMT3A
Entity type gene
Source Source Link

Details

PrimaryID1788
RefseqGeneNG_029465
SymbolDNMT3A
NameDNA methyltransferase 3 alpha
Chromosome2
Location2p23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-15
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsDNM3A_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000278 mitotic cell cycle
GO:0000775 chromosome, centromeric region
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001741 XY body
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006306 DNA methylation
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0006349 regulation of gene expression by genetic imprinting
GO:0007283 spermatogenesis
GO:0007568 aging
GO:0008134 transcription factor binding
GO:0009636 response to toxic substance
GO:0010212 response to ionizing radiation
GO:0010288 response to lead ion
GO:0010942 positive regulation of cell death
GO:0016363 nuclear matrix
GO:0030182 neuron differentiation
GO:0032355 response to estradiol
GO:0033189 response to vitamin A
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043045 DNA methylation involved in embryo development
GO:0043046 DNA methylation involved in gamete generation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0046872 metal ion binding
GO:0071230 cellular response to amino acid stimulus
GO:0071361 cellular response to ethanol
GO:0071456 cellular response to hypoxia
GO:0097284 hepatocyte apoptotic process
GO:0106363 protein-cysteine methyltransferase activity

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
DNMT3AZbtb18BioGRID11350943 details
DNMT3ATdgBioGRID17175537 details
DNMT3AMbd3BioGRID16322236 details
DNMT3AZbtb48BioGRID, IntAct26496610 details