Entity Details

Primary name ERBB2
Entity type gene
Source Source Link

Details

PrimaryID2064
RefseqGeneNG_007503
SymbolERBB2
Nameerb-b2 receptor tyrosine kinase 2
Chromosome17
Location17q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsERBB2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001042 RNA polymerase I core binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0008022 protein C-terminus binding
GO:0008045 motor neuron axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0010008 endosome membrane
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0032886 regulation of microtubule-based process
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033674 positive regulation of kinase activity
GO:0035556 intracellular signal transduction
GO:0038128 ERBB2 signaling pathway
GO:0038143 ERBB3:ERBB2 complex
GO:0042060 wound healing
GO:0042552 myelination
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0043209 myelin sheath
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043547 positive regulation of GTPase activity
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0090314 positive regulation of protein targeting to membrane
GO:1901185 negative regulation of ERBB signaling pathway
GO:2000145 regulation of cell motility

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
ERBB2ErbinMINT11278603 details
ERBB2Errfi1BioGRID11003669 details
ERBB2Usp19IntAct25036637 details
ERBB2Tor1aip1BioGRID26496610 details