Entity Details

Primary name TERT_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO70372
EntryNameTERT_MOUSE
FullNameTelomerase reverse transcriptase
TaxID10090
Evidenceevidence at protein level
Length1122
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesTert

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0001172 transcription, RNA-templated
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003721 telomerase RNA reverse transcriptase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0003968 RNA-directed 5'-3' RNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005697 telomerase holoenzyme complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006278 RNA-dependent DNA biosynthetic process
GO:0007004 telomere maintenance via telomerase
GO:0007005 mitochondrion organization
GO:0008022 protein C-terminus binding
GO:0010629 negative regulation of gene expression
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0022616 DNA strand elongation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030422 production of siRNA involved in RNA interference
GO:0031379 RNA-directed RNA polymerase complex
GO:0031647 regulation of protein stability
GO:0032092 positive regulation of protein binding
GO:0042162 telomeric DNA binding
GO:0042635 positive regulation of hair cycle
GO:0042645 mitochondrial nucleoid
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0046326 positive regulation of glucose import
GO:0046686 response to cadmium ion
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051087 chaperone binding
GO:0060253 negative regulation of glial cell proliferation
GO:0062103 double-stranded RNA biosynthetic process
GO:0070034 telomerase RNA binding
GO:0070200 establishment of protein localization to telomere
GO:0071456 cellular response to hypoxia
GO:0071897 DNA biosynthetic process
GO:0090399 replicative senescence
GO:0098680 template-free RNA nucleotidyltransferase
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903620 positive regulation of transdifferentiation
GO:1903704 negative regulation of production of siRNA involved in RNA interference
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904751 positive regulation of protein localization to nucleolus
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990572 TERT-RMRP complex
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000648 positive regulation of stem cell proliferation
GO:2000773 negative regulation of cellular senescence
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000477 Reverse transcriptase domainDomainDomain
IPR003545 Telomerase reverse transcriptaseFamilyFamily
IPR021891 Telomerase ribonucleoprotein complex - RNA-binding domainDomainDomain
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TERT_MOUSESMCA4_MOUSEDIP19571879 details
TERT_MOUSECTNB1_MOUSEDIP19571879 details