Entity Details

Primary name SIRT3
Entity type gene
Source Source Link

Details

PrimaryID23410
RefseqGene
SymbolSIRT3
Namesirtuin 3
Chromosome11
Location11p15.5
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSIR3_HUMAN

GO terms

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GOName
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006471 protein ADP-ribosylation
GO:0006476 protein deacetylation
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0008270 zinc ion binding
GO:0009060 aerobic respiration
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019899 enzyme binding
GO:0032024 positive regulation of insulin secretion
GO:0032991 protein-containing complex
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0043565 sequence-specific DNA binding
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070403 NAD+ binding
GO:1901671 positive regulation of superoxide dismutase activity
GO:1902553 positive regulation of catalase activity
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000378 negative regulation of reactive oxygen species metabolic process

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
SIRT3PpifUniProt21212461 details
SIRT3Acss2DIP16790548 details
SIRT3Acss1DIP16790548 details
SIRT3Opa1MINT24344202 details