Entity Details

Primary name SIRT1
Entity type gene
Source Source Link

Details

PrimaryID23411
RefseqGeneNG_050664
SymbolSIRT1
Namesirtuin 1
Chromosome10
Location10q21.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-22
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsSIR1_HUMAN

GO terms

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GOName
GO:0000012 single strand break repair
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000183 rDNA heterochromatin assembly
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0000731 DNA synthesis involved in DNA repair
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001650 fibrillar center
GO:0001678 cellular glucose homeostasis
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002039 p53 binding
GO:0002821 positive regulation of adaptive immune response
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005677 chromatin silencing complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006346 DNA methylation-dependent heterochromatin assembly
GO:0006476 protein deacetylation
GO:0006642 triglyceride mobilization
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007346 regulation of mitotic cell cycle
GO:0007517 muscle organ development
GO:0007569 cell aging
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0009267 cellular response to starvation
GO:0010629 negative regulation of gene expression
GO:0010824 regulation of centrosome duplication
GO:0010875 positive regulation of cholesterol efflux
GO:0010883 regulation of lipid storage
GO:0010906 regulation of glucose metabolic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0016575 histone deacetylation
GO:0016605 PML body
GO:0017136 NAD-dependent histone deacetylase activity
GO:0018394 peptidyl-lysine acetylation
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0030225 macrophage differentiation
GO:0030308 negative regulation of cell growth
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031393 negative regulation of prostaglandin biosynthetic process
GO:0031507 heterochromatin assembly
GO:0031648 protein destabilization
GO:0032007 negative regulation of TOR signaling
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0033210 leptin-mediated signaling pathway
GO:0033553 rDNA heterochromatin
GO:0033558 protein deacetylase activity
GO:0034391 regulation of smooth muscle cell apoptotic process
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035356 cellular triglyceride homeostasis
GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042326 negative regulation of phosphorylation
GO:0042393 histone binding
GO:0042542 response to hydrogen peroxide
GO:0042595 behavioral response to starvation
GO:0042632 cholesterol homeostasis
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043398 HLH domain binding
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044321 response to leptin
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045739 positive regulation of DNA repair
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0050872 white fat cell differentiation
GO:0051019 mitogen-activated protein kinase binding
GO:0051097 negative regulation of helicase activity
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0051898 negative regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060907 positive regulation of macrophage cytokine production
GO:0070301 cellular response to hydrogen peroxide
GO:0070403 NAD+ binding
GO:0070829 heterochromatin maintenance
GO:0070857 regulation of bile acid biosynthetic process
GO:0070914 UV-damage excision repair
GO:0070932 histone H3 deacetylation
GO:0071356 cellular response to tumor necrosis factor
GO:0071441 negative regulation of histone H3-K14 acetylation
GO:0071456 cellular response to hypoxia
GO:0071479 cellular response to ionizing radiation
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0090335 regulation of brown fat cell differentiation
GO:0090400 stress-induced premature senescence
GO:0106230 protein depropionylation
GO:0106231 protein-propionyllysine depropionylase activity
GO:1900034 regulation of cellular response to heat
GO:1900113 negative regulation of histone H3-K9 trimethylation
GO:1901215 negative regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1904179 positive regulation of adipose tissue development
GO:1990254 keratin filament binding
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990841 promoter-specific chromatin binding
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000480 negative regulation of cAMP-dependent protein kinase activity
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000619 negative regulation of histone H4-K16 acetylation
GO:2000655 negative regulation of cellular response to testosterone stimulus
GO:2000757 negative regulation of peptidyl-lysine acetylation
GO:2000773 negative regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence

Diseases

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