Entity Details

Primary name BACE1
Entity type gene
Source Source Link

Details

PrimaryID23621
RefseqGeneNG_029372
SymbolBACE1
Namebeta-secretase 1
Chromosome11
Location11q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsBACE1_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0008021 synaptic vesicle
GO:0008233 peptidase activity
GO:0009314 response to radiation
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010288 response to lead ion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0034205 amyloid-beta formation
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043525 positive regulation of neuron apoptotic process
GO:0045121 membrane raft
GO:0050435 amyloid-beta metabolic process
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0055037 recycling endosome
GO:0060134 prepulse inhibition
GO:0070931 Golgi-associated vesicle lumen
GO:0071280 cellular response to copper ion
GO:0071287 cellular response to manganese ion
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:1904646 cellular response to amyloid-beta
GO:1990000 amyloid fibril formation
GO:2000300 regulation of synaptic vesicle exocytosis

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
BACE1IappUniProt26840340 details
BACE1Clec4gMINT25957769 details
BACE1PrnpDIP17573534 details
BACE1AppMINT25957769 details