Entity Details

Primary name SAMHD1
Entity type gene
Source Source Link

Details

PrimaryID25939
RefseqGeneNG_017059
SymbolSAMHD1
NameSAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Chromosome20
Location20q11.23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSAMH1_HUMAN

GO terms

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GOName
GO:0000724 double-strand break repair via homologous recombination
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0004540 ribonuclease activity
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006203 dGTP catabolic process
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0008270 zinc ion binding
GO:0008832 dGTPase activity
GO:0009264 deoxyribonucleotide catabolic process
GO:0016032 viral process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016793 triphosphoric monoester hydrolase activity
GO:0032567 dGTP binding
GO:0035861 site of double-strand break
GO:0042802 identical protein binding
GO:0045088 regulation of innate immune response
GO:0046061 dATP catabolic process
GO:0051289 protein homotetramerization
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0097197 tetraspanin-enriched microdomain
GO:0110025 DNA strand resection involved in replication fork processing

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
SAMHD1Naa10BioGRID, IntAct26496610 details
SAMHD1Prdm16MINT30462309 details
SAMHD1MecomMINT30462309 details