Entity Details

Primary name APPL1
Entity type gene
Source Source Link

Details

PrimaryID26060
RefseqGeneNG_047003
SymbolAPPL1
Nameadaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Chromosome3
Location3p14.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDP13A_HUMAN

GO terms

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GOName
GO:0001726 ruffle
GO:0001786 phosphatidylserine binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006606 protein import into nucleus
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008286 insulin receptor signaling pathway
GO:0010008 endosome membrane
GO:0010762 regulation of fibroblast migration
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0023052 signaling
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032009 early phagosome
GO:0033211 adiponectin-activated signaling pathway
GO:0034143 regulation of toll-like receptor 4 signaling pathway
GO:0035091 phosphatidylinositol binding
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043422 protein kinase B binding
GO:0044354 macropinosome
GO:0044877 protein-containing complex binding
GO:0045088 regulation of innate immune response
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0048023 positive regulation of melanin biosynthetic process
GO:0048487 beta-tubulin binding
GO:0070062 extracellular exosome
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097708 intracellular vesicle
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1903076 regulation of protein localization to plasma membrane
GO:1905303 positive regulation of macropinocytosis
GO:1905450 negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
APPL1Adipor1IntAct16622416 details
APPL1EgfIntAct15016378 details
APPL1Inpp5bBioGRID, IntAct32203420 details
APPL1Rnf183BioGRID31732153 details