Entity Details

Primary name PTPN22
Entity type gene
Source Source Link

Details

PrimaryID26191
RefseqGeneNG_011432
SymbolPTPN22
Nameprotein tyrosine phosphatase non-receptor type 22
Chromosome1
Location1p13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPTN22_HUMAN

GO terms

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GOName
GO:0002230 positive regulation of defense response to virus by host
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0006914 autophagy
GO:0009898 cytoplasmic side of plasma membrane
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
GO:0030217 T cell differentiation
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032715 negative regulation of interleukin-6 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032817 regulation of natural killer cell proliferation
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035644 phosphoanandamide dephosphorylation
GO:0043508 negative regulation of JUN kinase activity
GO:0045088 regulation of innate immune response
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071225 cellular response to muramyl dipeptide
GO:0071663 positive regulation of granzyme B production
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1903753 negative regulation of p38MAPK cascade
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PTPN22Traf3IntAct23871208 details
PTPN22Skap2IntAct21719704 details