Entity Details

Primary name AGO2
Entity type gene
Source Source Link

Details

PrimaryID27161
RefseqGene
SymbolAGO2
Nameargonaute RISC catalytic component 2
Chromosome8
Location8q24.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsAGO2_HUMAN

GO terms

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GOName
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0003743 translation initiation factor activity
GO:0004521 endoribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0006412 translation
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008022 protein C-terminus binding
GO:0009791 post-embryonic development
GO:0010501 RNA secondary structure unwinding
GO:0010586 miRNA metabolic process
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016442 RISC complex
GO:0030422 production of siRNA involved in RNA interference
GO:0030425 dendrite
GO:0030522 intracellular receptor signaling pathway
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035087 siRNA loading onto RISC involved in RNA interference
GO:0035194 post-transcriptional gene silencing by RNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0035278 miRNA mediated inhibition of translation
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045947 negative regulation of translational initiation
GO:0045975 positive regulation of translation, ncRNA-mediated
GO:0046872 metal ion binding
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060964 regulation of gene silencing by miRNA
GO:0070062 extracellular exosome
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0070578 RISC-loading complex
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
GO:0090625 mRNA cleavage involved in gene silencing by siRNA
GO:0098808 mRNA cap binding
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:1901165 positive regulation of trophoblast cell migration
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:1990904 ribonucleoprotein complex

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
AGO2Tnrc6bDIP19838187 details
AGO2Eef1a1MINT17932509 details
AGO2Ybx1MINT17932509 details
AGO2Rnf183BioGRID31732153 details