Entity Details

Primary name HTRA2
Entity type gene
Source Source Link

Details

PrimaryID27429
RefseqGeneNG_012163
SymbolHTRA2
NameHtrA serine peptidase 2
Chromosome2
Location2p13.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-03-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsHTRA2_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0004252 serine-type endopeptidase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006508 proteolysis
GO:0006672 ceramide metabolic process
GO:0007005 mitochondrion organization
GO:0007568 aging
GO:0007628 adult walking behavior
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635 response to herbicide
GO:0009898 cytoplasmic side of plasma membrane
GO:0010822 positive regulation of mitochondrion organization
GO:0012501 programmed cell death
GO:0016020 membrane
GO:0016540 protein autoprocessing
GO:0019742 pentacyclic triterpenoid metabolic process
GO:0030900 forebrain development
GO:0031966 mitochondrial membrane
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0035458 cellular response to interferon-beta
GO:0035631 CD40 receptor complex
GO:0040014 regulation of multicellular organism growth
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257 cellular protein catabolic process
GO:0045786 negative regulation of cell cycle
GO:0048666 neuron development
GO:0051082 unfolded protein binding
GO:0071300 cellular response to retinoic acid
GO:0071363 cellular response to growth factor stimulus
GO:0097194 execution phase of apoptosis
GO:1901215 negative regulation of neuron death
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903146 regulation of autophagy of mitochondrion
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization
GO:1905370 serine-type endopeptidase complex
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
HTRA2Ripk1IntAct20125124 details
HTRA2XiapIntAct11604410 details