Entity Details

Primary name GSK3B
Entity type gene
Source Source Link

Details

PrimaryID2932
RefseqGeneNG_012922
SymbolGSK3B
Nameglycogen synthase kinase 3 beta
Chromosome3
Location3q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsGSK3B_HUMAN

GO terms

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GOName
GO:0001837 epithelial to mesenchymal transition
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005977 glycogen metabolic process
GO:0006468 protein phosphorylation
GO:0006983 ER overload response
GO:0007165 signal transduction
GO:0007212 dopamine receptor signaling pathway
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008286 insulin receptor signaling pathway
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010822 positive regulation of mitochondrion organization
GO:0010975 regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019082 viral protein processing
GO:0019901 protein kinase binding
GO:0021766 hippocampus development
GO:0030010 establishment of cell polarity
GO:0030011 maintenance of cell polarity
GO:0030424 axon
GO:0030425 dendrite
GO:0030516 regulation of axon extension
GO:0030877 beta-catenin destruction complex
GO:0031175 neuron projection development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032886 regulation of microtubule-based process
GO:0034236 protein kinase A catalytic subunit binding
GO:0034452 dynactin binding
GO:0035556 intracellular signal transduction
GO:0036016 cellular response to interleukin-3
GO:0042752 regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0046777 protein autophosphorylation
GO:0046827 positive regulation of protein export from nucleus
GO:0048156 tau protein binding
GO:0048814 regulation of dendrite morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050770 regulation of axonogenesis
GO:0051059 NF-kappaB binding
GO:0060079 excitatory postsynaptic potential
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071109 superior temporal gyrus development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0106027 neuron projection organization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0150101 regulation of microtubule anchoring at centrosome
GO:1900034 regulation of cellular response to heat
GO:1900181 negative regulation of protein localization to nucleus
GO:1900271 regulation of long-term synaptic potentiation
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904339 negative regulation of dopaminergic neuron differentiation
GO:1904646 cellular response to amyloid-beta
GO:1904781 positive regulation of protein localization to centrosome
GO:1904885 beta-catenin destruction complex assembly
GO:1904886 beta-catenin destruction complex disassembly
GO:1990909 Wnt signalosome
GO:2000077 negative regulation of type B pancreatic cell development
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000466 negative regulation of glycogen (starch) synthase activity

Diseases

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Interactions

20 interactions

InteractorPartnerSourcesPublicationsLink
GSK3BMapk1IntAct18045539 details
GSK3BDisc1IntAct19303846 details
GSK3BAxin1bhf-ucl, BioGRID, IntAct10330403 12421363 20368287 22682247 details
GSK3BNbr1BioGRID, IntAct20368287 details
GSK3BSpice1BioGRID, IntAct20368287 details
GSK3BDeaf1BioGRID, IntAct20368287 details
GSK3BKrba1BioGRID, IntAct20368287 details
GSK3BLzts2BioGRID, IntAct20368287 details
GSK3BMap3k11BioGRID, IntAct20368287 details
GSK3BNonoBioGRID, IntAct20368287 details
GSK3BProx2BioGRID, IntAct20368287 details
GSK3BPrune1BioGRID, IntAct20368287 details
GSK3BVta1BioGRID, IntAct20368287 details
GSK3BZbed3BioGRID, IntAct20368287 details
GSK3BWtipMINT21900206 details
GSK3BCtnnb1bhf-ucl, BioGRID, IntAct10481074 12417018 12421363 details
GSK3BDzip1DIP25860027 details
GSK3BH2-AaBioGRID20368287 details
GSK3BPrkacabhf-ucl11035810 details
GSK3BXpo1IntAct26673895 details