Entity Details

Primary name HLA-A
Entity type gene
Source Source Link

Details

PrimaryID3105
RefseqGeneNG_029217
SymbolHLA-A
Namemajor histocompatibility complex, class I, A
Chromosome6
Location6p22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-10-04
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsHLAA_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001913 T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002726 positive regulation of T cell cytokine production
GO:0003723 RNA binding
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0016567 protein ubiquitination
GO:0019731 antibacterial humoral response
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032729 positive regulation of interferon-gamma production
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042610 CD8 receptor binding
GO:0042612 MHC class I protein complex
GO:0042824 MHC class I peptide loading complex
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0062061 TAP complex binding
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2000568 positive regulation of memory T cell activation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
HLA-ABmpr1aBioGRID26496610 details
HLA-AArhgef17BioGRID26496610 details
HLA-ACep85lBioGRID26496610 details