Entity Details

Primary name HMGCR
Entity type gene
Source Source Link

Details

PrimaryID3156
RefseqGeneNG_011449
SymbolHMGCR
Name3-hydroxy-3-methylglutaryl-CoA reductase
Chromosome5
Location5q13.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsHMDH_HUMAN

GO terms

Show/Hide Table
GOName
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006695 cholesterol biosynthetic process
GO:0007399 nervous system development
GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0016021 integral component of membrane
GO:0016126 sterol biosynthetic process
GO:0019216 regulation of lipid metabolic process
GO:0019222 regulation of metabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0050709 negative regulation of protein secretion
GO:0070402 NADPH binding
GO:0120225 coenzyme A binding
GO:1900222 negative regulation of amyloid-beta clearance

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HMGCRRnf183BioGRID31732153 details