Entity Details

Primary name GSDMD_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9D8T2
EntryNameGSDMD_MOUSE
FullNameGasdermin-D
TaxID10090
Evidenceevidence at protein level
Length487
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesGsdmd

GO terms

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GOName
GO:0001786 phosphatidylserine binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0016021 integral component of membrane
GO:0022829 wide pore channel activity
GO:0031668 cellular response to extracellular stimulus
GO:0032731 positive regulation of interleukin-1 beta production
GO:0035915 pore formation in membrane of other organism
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0046931 pore complex assembly
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051260 protein homooligomerization
GO:0070269 pyroptosis
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0070300 phosphatidic acid binding
GO:0072559 NLRP3 inflammasome complex
GO:1901612 cardiolipin binding

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Inflammasome
Secreted

Domains

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DomainNameCategoryType
IPR007677 GasderminFamilyFamily
IPR040460 Gasdermin, pore forming domainDomainDomain
IPR041263 Gasdermin, PUB domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
GSDMD_MOUSECASP4_MOUSEDIP26375259 details