Entity Details

Primary name CNOT8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9D8X5
EntryNameCNOT8_MOUSE
FullNameCCR4-NOT transcription complex subunit 8
TaxID10090
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesCnot8

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000932 P-body
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0006351 transcription, DNA-templated
GO:0008284 positive regulation of cell population proliferation
GO:0017148 negative regulation of translation
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0031047 gene silencing by RNA
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0046872 metal ion binding
GO:0061014 positive regulation of mRNA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR027212 CCR4-NOT transcription complex subunit 8FamilyFamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR039637 CCR4-NOT transcription complex subunit 7/8/Pop2FamilyFamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
CNOT8_MOUSEBTG2_MOUSEBioGRID, IntAct20211142 details
CNOT8_MOUSEBTG1_MOUSEBioGRID, IntAct20211142 details
CNOT8_MOUSETLX3_MOUSEBioGRID, IntAct20211142 details
CNOT8_MOUSEBTG4_MOUSEDIP27065194 details