Entity Details

Primary name APP
Entity type gene
Source Source Link

Details

PrimaryID351
RefseqGeneNG_007376
SymbolAPP
Nameamyloid beta precursor protein
Chromosome21
Location21q21.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-08-24
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsA4_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000185 obsolete activation of MAPKKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001664 G protein-coupled receptor binding
GO:0001774 microglial cell activation
GO:0001878 response to yeast
GO:0001934 positive regulation of protein phosphorylation
GO:0001967 suckling behavior
GO:0002265 astrocyte activation involved in immune response
GO:0002576 platelet degranulation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005769 early endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005798 Golgi-associated vesicle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0005911 cell-cell junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006378 mRNA polyadenylation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006878 cellular copper ion homeostasis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0006979 response to oxidative stress
GO:0007155 cell adhesion
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007219 Notch signaling pathway
GO:0007409 axonogenesis
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008021 synaptic vesicle
GO:0008088 axo-dendritic transport
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008285 negative regulation of cell population proliferation
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009986 cell surface
GO:0009987 cellular process
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010823 negative regulation of mitochondrion organization
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014005 microglia development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016199 axon midline choice point recognition
GO:0016322 neuron remodeling
GO:0016358 dendrite development
GO:0016504 peptidase activator activity
GO:0019722 calcium-mediated signaling
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0019899 enzyme binding
GO:0030111 regulation of Wnt signaling pathway
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0030198 extracellular matrix organization
GO:0030424 axon
GO:0030546 signaling receptor activator activity
GO:0030549 acetylcholine receptor activator activity
GO:0030900 forebrain development
GO:0031093 platelet alpha granule lumen
GO:0031175 neuron projection development
GO:0031594 neuromuscular junction
GO:0031904 endosome lumen
GO:0032092 positive regulation of protein binding
GO:0032588 trans-Golgi network membrane
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033130 acetylcholine receptor binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034185 apolipoprotein binding
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0035066 positive regulation of histone acetylation
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035253 ciliary rootlet
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0042056 chemoattractant activity
GO:0042157 lipoprotein metabolic process
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043395 heparan sulfate proteoglycan binding
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044304 main axon
GO:0045048 protein insertion into ER membrane
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045821 positive regulation of glycolytic process
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046875 ephrin receptor binding
GO:0046914 transition metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0048143 astrocyte activation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048669 collateral sprouting in absence of injury
GO:0048786 presynaptic active zone
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050786 RAGE receptor binding
GO:0050803 regulation of synapse structure or activity
GO:0050808 synapse organization
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050867 positive regulation of cell activation
GO:0050885 neuromuscular process controlling balance
GO:0050890 cognition
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051087 chaperone binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051233 spindle midzone
GO:0051247 positive regulation of protein metabolic process
GO:0051260 protein homooligomerization
GO:0051262 protein tetramerization
GO:0051402 neuron apoptotic process
GO:0051425 PTB domain binding
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
GO:0051897 positive regulation of protein kinase B signaling
GO:0055037 recycling endosome
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
GO:0070062 extracellular exosome
GO:0070206 protein trimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070381 endosome to plasma membrane transport vesicle
GO:0070555 response to interleukin-1
GO:0070851 growth factor receptor binding
GO:0071280 cellular response to copper ion
GO:0071287 cellular response to manganese ion
GO:0071320 cellular response to cAMP
GO:0071874 cellular response to norepinephrine stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090647 modulation of age-related behavioral decline
GO:0097449 astrocyte projection
GO:0097645 amylin binding
GO:0098815 modulation of excitatory postsynaptic potential
GO:0106003 amyloid-beta complex
GO:0150003 regulation of spontaneous synaptic transmission
GO:1900122 positive regulation of receptor binding
GO:1900181 negative regulation of protein localization to nucleus
GO:1900221 regulation of amyloid-beta clearance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902950 regulation of dendritic spine maintenance
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903048 regulation of acetylcholine-gated cation channel activity
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903523 negative regulation of blood circulation
GO:1904022 positive regulation of G protein-coupled receptor internalization
GO:1904399 heparan sulfate binding
GO:1904472 positive regulation of endothelin production
GO:1904591 positive regulation of protein import
GO:1904646 cellular response to amyloid-beta
GO:1905606 regulation of presynapse assembly
GO:1905893 positive regulation of cellular response to thapsigargin
GO:1905896 positive regulation of cellular response to tunicamycin
GO:1905898 positive regulation of response to endoplasmic reticulum stress
GO:1905906 regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1905945 regulation of response to calcium ion
GO:1990000 amyloid fibril formation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990535 neuron projection maintenance
GO:1990761 growth cone lamellipodium
GO:1990777 lipoprotein particle
GO:1990812 growth cone filopodium
GO:2000310 regulation of NMDA receptor activity
GO:2000406 positive regulation of T cell migration
GO:2000463 positive regulation of excitatory postsynaptic potential

Diseases

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