Entity Details

Primary name IRF3
Entity type gene
Source Source Link

Details

PrimaryID3661
RefseqGeneNG_031810
SymbolIRF3
Nameinterferon regulatory factor 3
Chromosome19
Location19q13.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsIRF3_HUMAN

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016032 viral process
GO:0019904 protein domain specific binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0039530 MDA-5 signaling pathway
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050727 regulation of inflammatory response
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0071360 cellular response to exogenous dsRNA
GO:0071888 macrophage apoptotic process
GO:0097300 programmed necrotic cell death
GO:0098586 cellular response to virus
GO:1990837 sequence-specific double-stranded DNA binding

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
IRF3Tbk1DIP23746807 details
IRF3Hacd3IntAct25036637 details
IRF3MavsBioGRID25636800 details
IRF3Xpo1IntAct26673895 details