Entity Details

Primary name IRS1
Entity type gene
Source Source Link

Details

PrimaryID3667
RefseqGeneNG_015830
SymbolIRS1
Nameinsulin receptor substrate 1
Chromosome2
Location2q36.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsIRS1_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 protein kinase C binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030159 signaling receptor complex adaptor activity
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042593 glucose homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0071398 cellular response to fatty acid

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
IRS1Sik2BioGRID12624099 details
IRS1Pik3r1IntAct12679424 details
IRS1Grb2BioGRID, IntAct12679424 8662827 details
IRS1SypBioGRID8662827 details
IRS1Trp53BioGRID30578299 details
IRS1Mdm2BioGRID30578299 details