Entity Details

Primary name JAK3
Entity type gene
Source Source Link

Details

PrimaryID3718
RefseqGeneNG_007273
SymbolJAK3
NameJanus kinase 3
Chromosome19
Location19p13.11
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsJAK3_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002250 adaptive immune response
GO:0002731 negative regulation of dendritic cell cytokine production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005768 endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0030183 B cell differentiation
GO:0030218 erythrocyte differentiation
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035723 interleukin-15-mediated signaling pathway
GO:0035771 interleukin-4-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0045087 innate immune response
GO:0045221 negative regulation of FasL production
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0050868 negative regulation of T cell activation
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070232 regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071104 response to interleukin-9

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
JAK3Stat5aInnateDB23263556 details
JAK3Socs5BioGRID23990909 details