Entity Details

Primary name LCK
Entity type gene
Source Source Link

Details

PrimaryID3932
RefseqGeneNG_023387
SymbolLCK
NameLCK proto-oncogene, Src family tyrosine kinase
Chromosome1
Location1p35.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1993-10-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsLCK_HUMAN

GO terms

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GOName
GO:0000242 pericentriolar material
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008022 protein C-terminus binding
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0042169 SH2 domain binding
GO:0042493 response to drug
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0050690 regulation of defense response to virus by virus
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051249 regulation of lymphocyte activation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
LCKMbpBioGRID, MINT18067320 details
LCKCd3eBioGRID11855827 details
LCKPrdm16MINT30462309 details
LCKMecomMINT30462309 details
LCKLckBioGRID20360068 details