Entity Details

Primary name LDLR
Entity type gene
Source Source Link

Details

PrimaryID3949
RefseqGeneNG_009060
SymbolLDLR
Namelow density lipoprotein receptor
Chromosome19
Location19p13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsLDLR_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001618 virus receptor activity
GO:0002020 protease binding
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007616 long-term memory
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010899 regulation of phosphatidylcholine catabolic process
GO:0015914 phospholipid transport
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030169 low-density lipoprotein particle binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032050 clathrin heavy chain binding
GO:0034362 low-density lipoprotein particle
GO:0034381 plasma lipoprotein particle clearance
GO:0034382 chylomicron remnant clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0036020 endolysosome membrane
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045177 apical part of cell
GO:0051246 regulation of protein metabolic process
GO:0051248 negative regulation of protein metabolic process
GO:0061024 membrane organization
GO:0061771 response to caloric restriction
GO:0061889 negative regulation of astrocyte activation
GO:0070508 cholesterol import
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0097242 amyloid-beta clearance
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1903979 negative regulation of microglial cell activation
GO:1905167 positive regulation of lysosomal protein catabolic process
GO:1905907 negative regulation of amyloid fibril formation
GO:1990666 PCSK9-LDLR complex

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LDLRFlt1MINT17962812 details
LDLROxnad1BioGRID, IntAct26496610 details