Entity Details

Primary name LYN
Entity type gene
Source Source Link

Details

PrimaryID4067
RefseqGeneNG_029593
SymbolLYN
NameLYN proto-oncogene, Src family tyrosine kinase
Chromosome8
Location8q12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-21
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsLYN_HUMAN

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002553 histamine secretion by mast cell
GO:0002576 platelet degranulation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006991 response to sterol depletion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0010976 positive regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016301 kinase activity
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0030061 mitochondrial crista
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032868 response to insulin
GO:0033003 regulation of mast cell activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0034666 integrin alpha2-beta1 complex
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043015 gamma-tubulin binding
GO:0043200 response to amino acid
GO:0043208 glycosphingolipid binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043304 regulation of mast cell degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 transmembrane transporter binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045646 regulation of erythrocyte differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048678 response to axon injury
GO:0050777 negative regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051219 phosphoprotein binding
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060252 positive regulation of glial cell proliferation
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070062 extracellular exosome
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 negative regulation of mast cell proliferation
GO:0070668 positive regulation of mast cell proliferation
GO:0071300 cellular response to retinoic acid
GO:0090025 regulation of monocyte chemotaxis
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:0140031 phosphorylation-dependent protein binding
GO:1902532 negative regulation of intracellular signal transduction
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:2000670 positive regulation of dendritic cell apoptotic process

Diseases

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Interactions

13 interactions

InteractorPartnerSourcesPublicationsLink
LYNArap3IntAct15546919 details
LYNAsap1IntAct9819391 details
LYNSphk1IntAct16316995 details
LYNSphk2IntAct16316995 details
LYNCd36IntAct20037584 details
LYNTrim69IntAct20360068 details
LYNMyh10BioGRID, IntAct26496610 details
LYNRab11fip1BioGRID, IntAct26496610 details
LYNFlnbBioGRID, IntAct26496610 details
LYNCalml3BioGRID, IntAct26496610 details
LYNCoro1cBioGRID, IntAct26496610 details
LYNOsgepBioGRID, IntAct26496610 details
LYNSlain1BioGRID, IntAct26496610 details